FlyBase Allele Report: Dmel\Nipped-B[292.1]

General Information

Symbol

Dmel\Nipped-B^292.1

Species

D. melanogaster

Name

FlyBase ID

FBal0098361

Feature type

allele

Associated gene

Dmel\Nipped-B

Associated Insertion(s)

Carried in Construct

Also Known As

292.1

Key Links

Allele class

loss of function allele

Mutagen

gamma ray

Nature of the Allele

Allele class

loss of function allele

(Rollins et al., 1999)

Mutagen

gamma ray

(Rollins et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Cornelia de Lange syndrome

CEA

(Wu et al., 2015)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian behavior | female

(Wu et al., 2015)

abnormal memory | adult stage | male

(Wu et al., 2015)

abnormal neuroanatomy | adult stage | male

(Wu et al., 2015)

abnormal sleep | female

(Wu et al., 2015)

lethal (with Df(2R)M41A2)

(Coulthard et al., 2010)

lethal (with Nipped-B^34-3)

(Coulthard et al., 2010)

lethal (with Nipped-B^45-53)

(Coulthard et al., 2010)

lethal (with Nipped-B⁴⁰⁷)

(Coulthard et al., 2010)

lethal (with Nipped-B⁰²⁰⁴⁷)

(Coulthard et al., 2010)

lethal (with Nipped-B^ch(2)54)

(Coulthard et al., 2010)

lethal (with Nipped-B^IR13)

(Coulthard et al., 2010)

lethal (with Nipped-B^k02601a)

(Coulthard et al., 2010)

lethal (with Nipped-B^L5)

(Coulthard et al., 2010)

lethal (with Nipped-B^L7)

(Coulthard et al., 2010)

lethal (with Nipped-B^La6)

(Coulthard et al., 2010)

lethal (with Nipped-B^Lf)

(Coulthard et al., 2010)

lethal (with Nipped-B^LL)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC6)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC7)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC23)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC39)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC41)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC59)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC60)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC71)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC77)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC78)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC91)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC138)

(Coulthard et al., 2010)

lethal - all die before end of larval stage | recessive

(Rollins et al., 1999)

some die during larval stage | recessive

(Rollins et al., 1999)

visible | adult stage | female

(Wu et al., 2015)

Phenotype Manifest In

adult mushroom body | male

(Wu et al., 2015)

synaptonemal complex

(Gause et al., 2008)

wing blade

(Wu et al., 2015)

Detailed Description

Statement

Reference

Nipped-B^292.1/+ adult females have smaller wings compared to wild-type.

Nipped-B^292.1/+ males show more modest reduction in courtship attempts toward an unreceptive female over time compared to wild-type controls, and thusly conditioned heterozygote mutant male does not display reduced courting toward a receptive female as is observed in wild-type, suggesting defects in learning and short-term memory. Nipped-B^292.1/+ adult males also display morphological mushroom body defects with high frequency compared to controls.

Nipped-B^292.1/+ adult females sleep less overall than controls and this is due to reduced daytime sleep (shorter length of each sleep episode). The percentage of females showing arrhythmic circadian activity pattern is slightly higher than in controls but there is no significant difference in males.

Nipped-B^292.1/+ mutant adults do not display any seizure-like behaviors in response to either mechanical or thermal stress.

(Wu et al., 2015)

Chromosome cores and the synaptonemal complex fragment in germarial region 3 or stage 2 oocytes in Nipped-B^292.1 heterozygotes, which is substantially earlier than in wild type.

Nipped-B^292.1 heterozygotes do not show meiotic chromosome segregation defects.

(Gause et al., 2008)

50% of metaphase nuclei in the brains of Nipped-B^292.1/Nipped-B⁰²⁰⁴⁷ second instar larvae show precocious sister chromatid separation, in which the centromeric regions of the sister chromatids are somewhat detached from each other.

(Rollins et al., 2004)

Recessive lethality acts at the L2-L3 molt.

(Rollins et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Nipped-B[+]/Nipped-B^292.1 is an enhancer of visible phenotype of Ubx^bx-34e, su(Hw)^e2

(Rollins et al., 1999)

Other

Statement

Reference

Nipped-B^292.1, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

Nipped-B[+]/Nipped-B^292.1, mam^g2.1 has visible | dominant phenotype

(Rollins et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

Nipped-B^292.1 is an enhancer of phenotype of mam^g2.1

(Rollins et al., 1999)

Nipped-B[+]/Nipped-B^292.1 is an enhancer of wing phenotype of ct^L32, su(Hw)^e2

(Rollins et al., 1999)

NOT Enhancer of

Statement

Reference

Nipped-B^292.1 is a non-enhancer of phenotype of wg^l-17

(Rollins et al., 1999)

Nipped-B^292.1 is a non-enhancer of phenotype of ap^56f

(Rollins et al., 1999)

Nipped-B^292.1 is a non-enhancer of macrochaeta phenotype of N^spl-1

(Rollins et al., 1999)

Nipped-B^292.1 is a non-enhancer of phenotype of vg¹

(Rollins et al., 1999)

Nipped-B^292.1 is a non-enhancer of phenotype of ct^53d

(Rollins et al., 1999)

Nipped-B^292.1 is a non-enhancer of phenotype of Chi^e5.5

(Rollins et al., 1999)

Suppressor of

Statement

Reference

Nipped-B^292.1 is a suppressor of wing phenotype of N^nd-1

(Rollins et al., 1999)

Nipped-B^292.1 is a suppressor of eye phenotype of N^spl-1

(Rollins et al., 1999)

NOT Suppressor of

Statement

Reference

Nipped-B^292.1 is a non-suppressor of phenotype of N^Ax-E2

(Rollins et al., 1999)

Nipped-B^292.1 is a non-suppressor of macrochaeta phenotype of N^spl-1

(Rollins et al., 1999)

Other

Statement

Reference

Nipped-B^292.1, mam^g2.1/mam[+] has wing phenotype

(Rollins et al., 1999)

Nipped-B^292.1, ct^2s has wing phenotype

(Rollins et al., 1999)

Nipped-B[+]/Nipped-B^292.1, mam^g2.1 has wing phenotype

(Rollins et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Dominantly enhances the cut wing phenotype of ct^L32, su(Hw)^e2. Dominantly enhances the bithorax phenotype of Ubx^bx-34e, su(Hw)^e2. Shows slight dominant suppression of N^nd-1 wing nick phenotype. Has no effect on the bristle phenotype of N^spl-1, but suppresses the eye phenotype.

(Rollins et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Nipped-B⁰²⁰⁴⁷

(Rollins et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

292.1

(Coulthard et al., 2010, Rollins et al., 2004)

Nipped-B^292.1

(Wu et al., 2015, Coulthard et al., 2010, Gause et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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