FlyBase Allele Report: Dmel\ct[L32]

General Information

Symbol

Dmel\ct^L32

Species

D. melanogaster

Name

FlyBase ID

FBal0002014

Feature type

allele

Associated gene

Dmel\ct

Associated Insertion(s)

gypsy{}ct^L32

Carried in Construct

Also Known As

ct^L-32

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Jack et al., 1991)

Progenitor genotype

Associated Insertion(s)

gypsy{}ct^L32

Cytology

Description

gypsy insertion into the ct locus control region.

(Morcillo et al., 1996)

gypsy insertion maps to the region between the wing margin enhancer and the block of embryonic ct enhancers.

(Dorsett, 1993)

Gypsy insertion.

(Jack et al., 1991)

DNA coordinates (FBrf0042060) (0 is gypsy site in ct⁶): +19.3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Morcillo et al., 1996)

visible | recessive

(Morcillo et al., 1996, Jack and DeLotto, 1992)

Phenotype Manifest In

adult head

(Morcillo et al., 1996)

macrochaeta & wing

(Jack and DeLotto, 1992)

vibrissal bristle

(Dorsett, 1993)

wing

(Rollins et al., 1999, Morcillo et al., 1996, Dorsett, 1993, Jack and DeLotto, 1992)

Detailed Description

Statement

Reference

Homozygotes display cut wing and head capsule defects.

(Morcillo et al., 1996)

ct wing and vibrissae phenotype.

(Dorsett, 1993)

Homozygotes exhibit deletion of wing material from the margin resulting in the loss of 16% of wing tissue. Loss of tissue is caused by the lack of ct expression in the mechanoreceptors and noninnervating bristles, failure of these cells to differentiate results in cell death.

(Jack and DeLotto, 1992)

Extreme cut wing phenotype: loss of most bristles from entire wing margin and loss of cells from peripheral region of the wing blade.

(Jack et al., 1991)

cut wings displaced or missing vibrissae

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ct^L32, su(Hw)^e2 has visible phenotype, enhanceable by Chi[+]/Chi^g1

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has visible phenotype, enhanceable by Chi[+]/Chi^g96.1

(Morcillo et al., 1996)

Suppressed by

Statement

Reference

ct^L32/ct⁶ has visible phenotype, suppressible by su(Hw)^e2

(Morcillo et al., 1996)

Phenotype Manifest In

Enhanced by

Statement

Reference

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^222.3

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A³²³

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-C160.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by T(2;3)Nipped-C138.2

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-A^C25/+

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-D263.3

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-D341.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E43

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E299.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Df(2R)Nipped-E338

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^394.2

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^226.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A^357.2

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-A[+]/Nipped-A²

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B^292.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B^359.1

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴⁰⁷

(Rollins et al., 1999)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Chi[+]/Chi^g1

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by Chi[+]/Chi^g96.1

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by wg[+]/wg^l-17

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing margin phenotype, enhanceable by wg[+]/wg^l-17

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by ap^56f/ap[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by vg[+]/vg¹

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by vg[+]/vg^dd

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g10.2/mam[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g2.1/mam[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by mam^g5.0/mam[+]

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing phenotype, enhanceable by sd[+]/sd^g6

(Morcillo et al., 1996)

NOT Enhanced by

Statement

Reference

ct^L32, su(Hw)^e2 has wing phenotype, non-enhanceable by RpL38^45-72

(Rollins et al., 1999)

Suppressed by

Statement

Reference

ct^L32/ct⁶ has wing phenotype, suppressible by su(Hw)^e2

(Morcillo et al., 1996)

Other

Statement

Reference

ct^L32, su(Hw)^e2 has wing phenotype

(Morcillo et al., 1996)

ct^L32, su(Hw)^e2 has wing margin phenotype

(Morcillo et al., 1996)

Chi[+]/Chi^e5.5, ct^L32 has wing phenotype

(Morcillo et al., 1996)

Chi[+]/Chi^e5.5, ct^L32 has wing margin phenotype

(Morcillo et al., 1996)

ct^L32, mam^g2.1/mam[+] has wing phenotype

(Morcillo et al., 1996)

ct^L32, mam^g2.1/mam[+] has wing margin phenotype

(Morcillo et al., 1996)

ct^L32, sd[+]/sd² has wing phenotype

(Morcillo et al., 1996)

ct^L32, sd[+]/sd² has wing margin phenotype

(Morcillo et al., 1996)

ct^L32/ct[+], mam^g2.1 has wing phenotype

(Morcillo et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

ct^L32, su(Hw)^e2 double mutants display approximately 0.01 wing margin nicks per fly. The ct^L32, su(Hw)^e2 cut wing phenotype is dominantly enhanced by mutations at the 'Nipped' loci.

(Rollins et al., 1999)

ct^L32; su(Hw)^e2 flies display rare wing margin nicks, most wings display a wild type phenotype. ct^L32; su(Hw)^e2 flies heterozygous for wg^l-17, ap^56f or vg¹ display a weak ct wing phenotype, flies heterozygous for vg^dd display a significant ct wing phenotype. Chi^e5.5; ct^L32, mam^g2.1; ct^L32 and sd²; ct^L32 double heterozygotes display a visible cut wing phenotype.

(Morcillo et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Lim.

Comments

Strong ct allele.

(Jack and DeLotto, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ct^L-32

(Rollins et al., 1999, Morcillo et al., 1996, Dorsett, 1993, Jack and DeLotto, 1992, Jack et al., 1991)

ct^L32

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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