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General Information
Symbol
Dmel\MedJF02218
Species
D. melanogaster
Name
FlyBase ID
FBal0244896
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-medRNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing MedJF02218 under the control of Scer\GAL4ppk.PU results in a significantly reduced number of branch points in the dendrites of class IV dendritic arborizing neurons in third instar larvae compared to wild-type controls.

Expression of MedJF02218 under the control of Scer\GAL4A9 results in the loss of distal parts of the L3, L4 and L5 wing veins and a decrease in wing size.

The adulthood-only expression of MedJF02218 under the control of Scer\GAL4esg.PU (in combination with Gal80[ts], for temporal regulation of expression) leads to a significant decrease in the relative and absolute size of secondary cell nuclei compared to neighboring main cells and wild-type controls; this expression does not affect the size of main cell nuclei compared to controls. The adulthood-only expression under the control of Scer\GAL4dsx.KI (and Gal80[ts]) leads to a significant decrease in the number of secretory vesicles within accessory gland secondary cells, associated with a significant decrease in the size of the largest multivesicular body/lysosome, as compared to controls; there is also a severe decrease in the secretion of (CD63-positive) exosomes into the accessory gland lumen.

The adulthood-only expression of MedJF02218 under the combined control of Scer\GAL4spi-NP0261 and Gal80[ts] also results in both virgin and mated males showing a significant increase in the number of dense core granule compartments within accessory gland secondary cells, as compared to matched controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT Enhancer of
Suppressor of
NOT Suppressor of
Other
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The thickened wing vein phenotype of adults expressing anchorGD3613 under the control of Scer\GAL4A9 is partially suppressed by addition of MedJF02218. The decreased wing size phenotype of adults expressing MedJF02218 under the control of Scer\GAL4A9 is suppressed by addition of anchorGD3613.

Co-expression of MadKK109050 and MedJF02218 under the control of Scer\GAL4P2.4.Pdf reduces the strength of locomotor rhythmicity and induces strong arrhythmicity.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
MedJF02218
Name Synonyms
Secondary FlyBase IDs
    References (9)