FB2025_05 , released December 11, 2025
Allele: Dmel\ykiJF03119
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General Information
Symbol
Dmel\ykiJF03119
Species
D. melanogaster
Name
FlyBase ID
FBal0244933
Feature type
allele
Associated gene
Dmel\yki
Associated Insertion(s)
Carried in Construct
P{TRiP.JF03119}
Also Known As
UAS-Yki RNAi, Yki RNAi, UAS-ykiRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF03119}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF03119
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Noonan syndrome
      modeled by Hsap\RAF1gof.UAS
      (Yu et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing ykiJF03119 under the control of Scer\GAL4tin.CΔ4 have increased ventricular diameters at the end of systole and diastole and a reduction in fractional shortening compared with controls. The heart walls are thinner compared with controls but cardiomyocyte number is the same as in controls. Average cardiomyocyte ploidy is unaffected.

      (Yu et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of ykiJF03119 suppresses the cardiac hypertrophy seen in flies expressing Hsap\RAF1gof.Scer\UAS under the control of Scer\GAL4tin.CΔ4, returning the ventricular diameter at the end of diastole (EDD) and heart wall thickness to control levels. The cardiomyocytes abnormalities are partially suppressed.

      (Yu et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ykiJF03119
      ykiRNAi1
      (Chen et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (18)