FlyBase Allele Report: Dmel\tej[48-5]

General Information

Symbol

Dmel\tej^48-5

Species

D. melanogaster

Name

FlyBase ID

FBal0244983

Feature type

allele

Associated gene

Dmel\tej

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Patil and Kai, 2010)

Mutagen

P-element activity

(Patil and Kai, 2010)

Progenitor genotype

P{EPgy2}EY08611

(Patil and Kai, 2010)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion of 1.6kb of genomic sequence which encompasses the potential start codon of tej.

(Patil and Kai, 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:14,302,090..14,303,683 [-]

Comment:

A ~1.6kb deletion resulting from the imprecise excision of P{EPgy2}EY08611. Mapped deletion endpoints are precise and were mapped from reported sequence.

(Patil and Kai, 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Patil and Kai, 2010)

viable

(Patil and Kai, 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Eggs derived from mutant females have normal dorsal appendages.

(Patil and Kai, 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

tapas¹²⁵, tej^48-5 has female sterile phenotype

(Patil et al., 2014)

tapas¹²⁵, tej^48-5 has male sterile | progressive phenotype

(Patil et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

tapas¹²⁵, tej^48-5 has female germline cell phenotype

(Patil et al., 2014)

tapas¹²⁵, tej^48-5 has male germline cell phenotype

(Patil et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

tej^48-5 tapas¹²⁵ double mutant females are sterile, while double mutant males are fertile only for the first few days after eclosion. Progressive degeneration of the germline cells is seen in both cases. Apoptotic cells are seen in the germarium in double mutant tej^48-5 tapas¹²⁵ ovaries and testes, in contrast to wild type or single mutant germaria. Double mutant oocytes show a severe defect in polarity establishment.

Germline stem cells appear to be maintained in the gonads in double mutant tej^48-5 tapas¹²⁵ males and females.

(Patil et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

tej^48-5 is rescued by tej^UASp.Tag:HA/Scer\GAL4^{VP16.nanos.UTR}

(Patil and Kai, 2010)

tej^48-5 is rescued by Scer\GAL4^{VP16.nanos.UTR}/tej^{NT.UASp.Tag:HA}

(Patil and Kai, 2010)

Partially rescued by

tej^48-5 is partially rescued by tej^{CT.UASp.Tag:HA}/Scer\GAL4^{VP16.nanos.UTR}

(Patil and Kai, 2010)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tej^48-5

(Lin et al., 2023, Lim et al., 2022, Primus et al., 2019, Patil et al., 2014, Anand and Kai, 2012, Patil and Kai, 2010)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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