FB2026_02 , released June 18, 2026
Allele: Scer\GAL4NP7177
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General Information
Symbol
Scer\GAL4NP7177
Species
S. cerevisiae
Name
FlyBase ID
FBal0245032
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}amnNP7177
Carried in Construct
Also Known As
NP7177
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}amnNP7177
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        adult stage
        adult dopaminergic PAM neuron
        (Flybrain Neuron Database et al., 2018.6.28, Tanaka et al., 2008)
        mushroom body gamma lobe slice 4
        (Tanaka et al., 2008)
        mushroom body beta' anterior-posterior layer
        (Tanaka et al., 2008)
        mushroom body beta' lobe slice 1
        (Tanaka et al., 2008)
        mushroom body beta' lobe slice 2
        (Tanaka et al., 2008)
        mushroom body beta' middle layer
        (Tanaka et al., 2008)
        adult stage | female
        adult brain | restricted
        (Shuai et al., 2015)
        mushroom body extrinsic neuron
        (Shuai et al., 2015)
        mushroom body gamma lobe slice 3
        (Shuai et al., 2015)
        mushroom body gamma lobe slice 4
        (Shuai et al., 2015)
        mushroom body gamma lobe slice 5
        (Shuai et al., 2015)
        mushroom body beta' lobe slice 1
        (Shuai et al., 2015)
        mushroom body beta' lobe slice 2
        (Shuai et al., 2015)
        dopaminergic PAM neuron 14
        (Shuai et al., 2015)
        dopaminergic PAM neuron 13
        (Shuai et al., 2015)
        Additional Information
        Statement
        Reference

        ScerGAL4amn-NP7177 drives expression in mushroom body extrinsic neurons, including the mushroom body anterior inferior medial cell and dopaminergic PAM neurons 13 and 14, that innervate mushroom body gamma lobe slice 3, mushroom body gamma lobe slice 4, mushroom body gamma lobe slice 5, mushroom body beta' lobe slice 1 and mushroom body beta' lobe slice 2. Expression partially overlaps with that driven by EcollexAGMR24E12 in 11 dopaminergic PAM neurons 13 and 14.

        (Shuai et al., 2015)

        Projections of the mushroom body anterior inferior medial neurons innervate the anterior stratum of the beta' lobe segment 1, and/or throughout the middle and posterior strata of segment 2.

        (Tanaka et al., 2008)
         
        Marker for
        adult antennal lobe projection neuron VL1 ilPN
        (Tanaka et al., 2008)
        Reflects expression of
        amn
        (Tanaka et al., 2008)
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4NP7177 neurons, in combination with a Gal80[ts] transgene to restrict expression to 1 day prior to training and testing, significanlty improves 3 hour aversive olfactory memory, but not immediate short term memory, compared to controls; 3 hour memory following a 2 min cold shock is similar to that of controls; there is no effect on shock reactivity or olfactory acuity, compared to controls.

        (Shuai et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Scer\GAL4NP7177
        Scer\GAL4amn-NP7177
        Name Synonyms
        Secondary FlyBase IDs
          References (5)