FlyBase Allele Report: Dmel\Madm[UAS.cGa]

General Information

Symbol

Dmel\Madm^UAS.cGa

Species

D. melanogaster

Name

FlyBase ID

FBal0245103

Feature type

allele

Associated gene

Dmel\Madm

Associated Insertion(s)

Carried in Construct

P{UAS-Madm.G}

Also Known As

UAS-Madm

Key Links

Transgenic product class

cDNA

(Gluderer et al., 2010)

wild_type

(Gluderer et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Gluderer et al., 2010)

wild_type

(Gluderer et al., 2010)

Mutagen

in vitro construct

(Gluderer et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-Madm.G}

Cytology

Description

UASt regulatory sequences drive expression of Madm coding sequences corresponding to LD28567.

(Gluderer et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Madm

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Madm^Scer\UAS.cGa under the control of Scer\GAL4^esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) does not significantly affect proliferation or cell number in the midgut.

(Nie et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Madm^UAS.cGa, Scer\GAL4^NP5130, bun^A.UAS has increased cell number | adult stage phenotype

(Nie et al., 2015)

Madm^UAS.cGa, Scer\GAL4^NP5130, bun^{A.UAS.C.Tag:SBP} has increased cell number | adult stage phenotype

(Nie et al., 2015)

Madm^UAS.cGa, Scer\GAL4^NP5130, bun^{A.UAS.C.Tag:SBP} has abnormal mitotic cell cycle | adult stage phenotype

(Nie et al., 2015)

Madm^UAS.cGa, Scer\GAL4^NP5130, bun^{A.UAS.N.Tag:SBP} has increased cell number | adult stage phenotype

(Nie et al., 2015)

Phenotype Manifest In

Other

Statement

Reference

Madm^UAS.cGa, Scer\GAL4^NP5130, bun^A.UAS has adult midgut | adult stage phenotype

(Nie et al., 2015)

Madm^UAS.cGa, Scer\GAL4^NP5130, bun^{A.UAS.C.Tag:SBP} has adult midgut | adult stage phenotype

(Nie et al., 2015)

Madm^UAS.cGa, Scer\GAL4^NP5130, bun^{A.UAS.N.Tag:SBP} has adult midgut | adult stage phenotype

(Nie et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Madm^Scer\UAS.cGa with bun^{A.Scer\UAS.N.T:Zzzz\SBP}, bun^{A.Scer\UAS.C.T:Zzzz\SBP}, or bun^A.Scer\UAS, under the control of Scer\GAL4^esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) leads to a significant increase in cell proliferation in the midgut, and an increase in the number of midgut cells, as compared to controls or flies expressing either construct alone.

Co-expression of Madm^Scer\UAS.cGa with bun^{A.Scer\UAS.T:SV40\nls-largeT} or bun^{A.Scer\UAS.T:Zzzz\SBP,T:SV40\nls-largeT} under the control of Scer\GAL4^esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) does not significantly affect proliferation or cell number in the midgut.

(Nie et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Madm^UAS.cGa/Scer\GAL4^arm.PS rescues Madm^3T4

(Gluderer et al., 2010)

Madm^UAS.cGa/Scer\GAL4^arm.PS rescues Madm^2U3

(Gluderer et al., 2010)

Madm^UAS.cGa/Scer\GAL4^arm.PS rescues Madm^4S3

(Gluderer et al., 2010)