FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ppk28Δ
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General Information
Symbol
Dmel\ppk28Δ
Species
D. melanogaster
Name
FlyBase ID
FBal0245234
Feature type
allele
Associated gene
Dmel\ppk28
Associated Insertion(s)
Carried in Construct
Also Known As
ppk28 mutant
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Cameron et al., 2010)
Mutagen
recombination
(Cameron et al., 2010)
FLPase
(Cameron et al., 2010)
P-element activity
(Chen et al., 2010)
Progenitor genotype
PBac{RB}e02329
(Cameron et al., 2010, Chen et al., 2010)
PBac{WH}f05788
(Cameron et al., 2010, Chen et al., 2010)
Cytology
Description

Recombination between the two progenitor insertions has resulted in the deletion of the sequence between them, removing 1.769kb including the ppk28 gene.

(Cameron et al., 2010)

Excision of PBac{WH}f05788 and PBac{RB}e02329 generates a deletion in ppk28.

(Chen et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:16,805,493..16,809,340 [+]
Comment:

Recombination between the two progenitor insertions has resulted in the deletion of the intervening sequence between them.

(Cameron et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ppk28Δ mutant adult females have no difference in preference for softer plain, or 100 mM sucrose-containing, agarose for egg laying, compared to controls.

      (Wu et al., 2019)

      ppk28Δ mutant adults have no difference in spiking of mechanosensory neurons of the labellar taste bristles or labellar taste pegs in response to mechanical stimuli, compared to controls.

      (Zhou et al., 2019)

      ppk28Δ homozygous adults have significantly reduced 3-min, 3-hour and 24-hour associative olfactory water-reward memory, compared to controls.

      (Shyu et al., 2017)

      ppk28Δ mutants are defective in water learning, despite displaying normal olfactory acuity and naive water-seeking behavior.

      (Lin et al., 2014)

      Mutant males show normal courtship behaviour.

      (Lu et al., 2012)

      Extracellular bristle recordings of mutant l-type labellar taste sensilla show a complete loss of the response to water in mutant animals, while the response to sucrose is not significantly different from the response in control animals.

      Mutant flies drink less water than control flies (as assayed by the drinking time), while sucrose consumption is not significantly different from wild type.

      (Cameron et al., 2010)

      ppk28Δ mutant flies exhibit behavioral defects and abolishment of water-elicited spiking. ppk28Δ flies exhibit a markedly reduced water-elicited proboscis extension reflex. ppk28Δ mutants exhibit a wild-type proboscis extension reflex to sugar and bitter substances.

      (Chen et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ppk28Δ is rescued by ppk28+t4

      (Chen et al., 2010)
      Partially rescued by

      ppk28Δ is partially rescued by ppk28UAS.cCa/Scer\GAL4ppk28.PC

      (Cameron et al., 2010)
      Comments

      The electrophysiological response of l-type labellar taste sensilla to water is partially restored in ppk28Δ animals by expression of ppk28Scer\UAS.cCa under the control of Scer\GAL4ppk28.PC. The rescued flies also show normal water consumption (as assayed by the drinking time).

      (Cameron et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ppk28 mutant
      (Lee et al., 2025, Cameron et al., 2010)
      ppk28Δ
      (Li et al., 2022, Zhou et al., 2019, Lin et al., 2014, Chen et al., 2010)
      Δppk28
      (Lu et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)