FlyBase Allele Report: Dmel\magu[2]

General Information

Symbol

Dmel\magu²

Species

D. melanogaster

Name

FlyBase ID

FBal0245301

Feature type

allele

Associated gene

Dmel\magu

Associated Insertion(s)

Carried in Construct

Also Known As

pent²

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

FLPase

Nature of the Allele

Allele class

Mutagen

FLPase

(Vuilleumier et al., 2010)

Progenitor genotype

PBac{WH}magu^f02256

(Vuilleumier et al., 2010)

P{XP}magu^d00269

(Vuilleumier et al., 2010)

Cytology

Description

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in a deletion of part of the magu gene.

(Vuilleumier et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:10,056,807..10,058,453 [+]

Comment:

Deletion generated by FLP-catalyzed recombination using the FRT-containing transposons P{XP}magu^d00269 and PBac{WH}magu^f02256.

(Vuilleumier et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | recessive

(Vuilleumier et al., 2010)

increased cell death | dominant | larval stage

(Merino et al., 2022)

visible | recessive

(Vuilleumier et al., 2010)

Phenotype Manifest In

wing blade

(Vuilleumier et al., 2010)

wing disc | larval stage

(Merino et al., 2022)

wing vein L5

(Vuilleumier et al., 2010)

Detailed Description

Statement

Reference

magu² mutant wings display a characteristic truncation of longitudinal vein 5 (L5) and are considerably smaller than wild-type. The size deficit of magu² mutant wings are mostly confined to lateral regions of the wing and reflected a reduction in cell numbers rather than cell size. Both venation and size deficits of magu² mutant wings can be traced backed to larval stages of wing development.

(Vuilleumier et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

magu² has increased cell death | larval stage | dominant phenotype, non-enhanceable by dally^UAS.cJa/Scer\GAL4^C-765

(Merino et al., 2022)

magu² has visible | recessive phenotype, non-enhanceable by dally^MH32

(Vuilleumier et al., 2010)

Suppressed by

Statement

Reference

magu² has increased cell death | dominant | larval stage phenotype, suppressible by Scer\GAL4^C-765/fwe^KK109356

(Merino et al., 2022)

magu² has visible | recessive phenotype, suppressible by tkv⁸/tkv[+]

(Vuilleumier et al., 2010)

NOT suppressed by

Statement

Reference

magu² has increased cell death | dominant | larval stage phenotype, non-suppressible by dally^UAS.cJa/Scer\GAL4^C-765

(Merino et al., 2022)

magu² has visible | recessive phenotype, non-suppressible by dally^MH32

(Vuilleumier et al., 2010)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

magu² has wing disc | larval stage phenotype, non-enhanceable by dally^UAS.cJa/Scer\GAL4^C-765

(Merino et al., 2022)

magu² has wing vein L5 phenotype, non-enhanceable by dally^MH32

(Vuilleumier et al., 2010)

Suppressed by

Statement

Reference

magu² has wing disc | larval stage phenotype, suppressible by Scer\GAL4^C-765/fwe^KK109356

(Merino et al., 2022)

magu² has wing vein L5 phenotype, suppressible by tkv⁸/tkv[+]

(Vuilleumier et al., 2010)

NOT suppressed by

Statement

Reference

magu² has wing disc | larval stage phenotype, non-suppressible by dally^UAS.cJa/Scer\GAL4^C-765

(Merino et al., 2022)

magu² has wing vein L5 phenotype, non-suppressible by dally^MH32

(Vuilleumier et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous tkv⁸ suppresses the adult wing patterning defects of homozygous magu² mutants.

The wing defects seen in magu², dally^MH32 double mutants appear similar to the lateral patterning defects of magu² single mutants.

(Vuilleumier et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

magu² is partially rescued by Scer\GAL4^unspecified/magu^UAS.Tag:V5

(Vuilleumier et al., 2010)

Comments

The wing patterning phenotype of magu² mutants is restored when magu^Scer\UAS.cVa expression is restricted to any compartment or region of the wing disc. However, 'misplacing' the source of magu^Scer\UAS.cVa results in wings with abnormal sizes and altered proportions.

(Vuilleumier et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

magu²

pent²

(Ell et al., 2024, Merino et al., 2022, Romanova-Michaelides et al., 2022, Vuilleumier et al., 2010)

pentagone²

(Merino et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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