FlyBase Allele Report: Dmel\bsk[JF01275]

General Information

Symbol

Dmel\bsk^JF01275

Species

D. melanogaster

Name

FlyBase ID

FBal0245567

Feature type

allele

Associated gene

Dmel\bsk

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01275}

Also Known As

UAS-bsk RNAi, UAS-bsk-RNAi, JNK RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.JF01275}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01275

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates hematologic cancer

modeled by mxc¹

(Takarada et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell death | adult stage | nutrition conditional, with Scer\GAL4^GR1

(Etchegaray et al., 2012)

abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4^repo

(Nelson et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

The healthy egg chambers in starved flies expressing bsk^JF01275 under the control of Scer\GAL4^GR1 appear wild type, and degenerating egg chambers begin the normal process of follicle cell (FC) engulfment, including the enlargement of the FCs and uptake of the germline debris. However engulfment defects are seen later in the process. The FCs fails to enlarge and the FC nuclei become pycnotic. Nurse cell nuclei are not taken up by the FCs. The nurse cell nuclei also failed to fragment properly, making it difficult to assess the specific phases of degeneration. Very few degenerating egg chambers are seen in unstarved flies.

(Etchegaray et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

bsk^JF01275/Scer\GAL4^He.PZ is a suppressor of abnormal cell migration | larval stage phenotype of mxc¹

(Takarada et al., 2023)

bsk^JF01275/Scer\GAL4^He.PZ is a suppressor of abnormal cell adhesion | larval stage phenotype of mxc¹