FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mdh22
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General Information
Symbol
Dmel\Mdh22
Species
D. melanogaster
Name
FlyBase ID
FBal0246392
Feature type
allele
Associated gene
Dmel\Mdh2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wang et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: D173G.

(Wang et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:18,228,006..18,228,006 [+]
Nucleotide change:

A18228006G

Amino acid change:

D173G | Mdh2-PA

Reported amino acid change:

D173G

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Wang et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      46% of Mdh21/Mdh22 pupae at 24 hr APF show persistent larval salivary glands and none eclose.

      (Wang et al., 2010)

      Mutants show defects in destruction of the larval salivary glands, having persistant larval salivary glands at the pupal stage.

      (Wang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Mdh22/Mdh21 is rescued by Mdh2Tag:MYC

      (Wang et al., 2010)
      Comments

      One copy of Mdh2T:Hsap\MYC restores normal salivary gland cell death and efficiently rescues pupal lethality in Mdh21/Mdh22 animals.

      (Wang et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      6753
      (Wang et al., 2008)
      CG79986753
      (Wang et al., 2010)
      Mdh22
      (Wang et al., 2010)
      l(3)psg76753
      mdh22
      (Ihry and Bashirullah, 2014)
      mdh2psg7a
      (Ihry and Bashirullah, 2014)
      psg7a
      (Ihry and Bashirullah, 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)