FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gishMB896
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General Information
Symbol
Dmel\gishMB896
Species
D. melanogaster
Name
FlyBase ID
FBal0246853
Feature type
allele
Associated gene
Dmel\gish
Associated Insertion(s)
P{lArB}gishMB896
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{lArB}gishMB896
    Cytology
    Description

    Insertion in the second intron.

    (Tan et al., 2010)
    Allele components
    Component
    Use(s)
    Inserted element
    P{lArB}
    Encoded product / tool
    lacZ
    Tagged with
    Tag:NLS(P)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes show a significant impairment in memory retention after olfactory classical conditioning compared to wild-type flies. Significant impairment is seen at 3 minutes, 30 minutes and 3 hours after training. Homozygous flies show a more severe impairment than heterozygotes in 3 minute and 3 hour memory retention after olfactory conditioning.

        Heterozygotes and homozygotes show normal shock and odour avoidance.

        (Tan et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        gishMB896 is partially rescued by Scer\GAL4Mef2.247/gishUAS.cTa

        (Tan et al., 2010)

        gishMB896 is partially rescued by Scer\GAL4238Y/gishUAS.cTa

        (Tan et al., 2010)
        Not rescued by

        gishMB896 is not rescued by Scer\GAL4c305a/gishUAS.cTa

        (Tan et al., 2010)

        gishMB896 is not rescued by gishUAS.cTa/Scer\GAL4c739

        (Tan et al., 2010)
        Comments

        Expression of gishScer\UAS.cTa under the control of either Scer\GAL4Mef2.247 or Scer\GAL4238Y partially rescues the 3 minute memory impairment of gishMB896 homozygotes after olfactory associative training.

        Expression of gishScer\UAS.cTa under the control of either Scer\GAL4c305a or Scer\GAL4c739 does not rescue the 3 minute memory impairment of gishMB896 homozygotes after olfactory associative training.

        Experiments in which the temperature-sensitive Scer\GAL80ts.αTub84B allele is used to restrict Scer\GAL4 expression to particular developmental stages by using temperature shifts show that expression of gishScer\UAS.cTa under the control of either Scer\GAL4Mef2.247 or Scer\GAL4238Y only during the adult stage partially rescues the memory impairment of gishMB896 homozygotes after olfactory conditioning, but that expression of gishScer\UAS.cTa under the control of either Scer\GAL4Mef2.247 or Scer\GAL4238Y only during development (prior to the adult stage) does not rescue the memory impairment of gishMB896 homozygotes.

        (Tan et al., 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        gishMB896
        (Tan et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)