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General Information
Symbol
Dmel\Mt299
Species
D. melanogaster
Name
FlyBase ID
FBal0246943
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dnmt299
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Imprecise excision of the EP(2)GE15695 P-element, deleting the proximal portion of Mt2 and leaving a remnant of the EP element upstream. The 3' end of the deletion is reported to occur somewhere in motif VIII (VPNTRYR) of Mt2 (exact position unspecified). Position of mutation on reference sequence inferred by FlyBase curator.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a proximal deletion of the inserted P{EP} element, and the fusion of the remainder of the element to the 3' half of the Mt2 coding region, thus deleting large parts of the Mt2 gene, including motifs I-VII and part of motif VIII.

Insertion components
P{?EP}Mt299
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mt299 mutant flies succumb more readily to Drosophila C Virus (DCV) infection than controls.

Mutants show a reduced mean lifespan compared to controls when raised continuously at 29[o]C.

Mutants show elevated sensitivity to paraquat and to H[[2]]O[[2]] compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Mt2genTG.T:Avic\GFP-EGFP rescues the increased lethality seen in Mt299 mutant flies in response to Drosophila C Virus (DCV) infection.

Mt2genTG partially or fully restores life span in Mt299 flies raised continuously at 29[o]C. Mt2genTG partially rescues the increased sensitivity of Mt299 flies to H[[2]]O[[2]].

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)