FB2026_02 , released June 18, 2026
Allele: Dmel\Dlic1
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General Information
Symbol
Dmel\Dlic1
Species
D. melanogaster
Name
FlyBase ID
FBal0247638
Feature type
allele
Associated gene
Dmel\Dlic
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Satoh et al., 2008)
Progenitor genotype
Cytology
Description

Lesion resulting in a splicing error. al161027.

(Satoh et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Terminal cells in Dlic1 mutant trachea have thin cytoplasmic branches that lack air filling. Seamless tubes do not extend into these branches, although acetylated microtubules often do. Formation of filopodia at branch tips is disrupted and ectopic seamless tubes that are not air filled are detected near the nucleus. Discontinuous apical membrane fragments are found in terminal branches lacking seamless tubes and are associated with microtubule tracts.

      (Schottenfeld-Roames and Ghabrial, 2012)

      Dlic1/Dlic2, Dlic1/Df(1)v-N48 or Dlic1/DlicG0065 dendrites of class IV da neurons at 44-48 hr after egg laying show a significant undergrowth phenotype.

      (Satoh et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wkd220/Df(3R)Exel6276 does not enhance the ectopic seamless tube phenotype seen in Dlic1 mutant tracheal terminal cell clones.

      Expression of Rab35Q67L.Scer\UAS.P\T.T:Avic\GFP-YFP under the control of Scer\GAL4btl.PS does not suppress the ectopic tube phenotype seen in Dlic1 mutant tracheal cell clones.

      (Schottenfeld-Roames and Ghabrial, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Dlic1 is rescued by Scer\GAL4unspecified/DlicUAS.cSa.EGFP

      (Satoh et al., 2008)
      Comments

      Expression of DlicScer\UAS.T:Avic\GFP-EGFP.cSa under the control of Scer\GAL4unspecified rescues the mutant dendritic arborization phenotype of Dlic1 mutant neurons.

      (Satoh et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dlic1
      dlic1
      (Satoh et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)