FB2026_02 , released June 18, 2026
Allele: Dmel\Dlic2
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General Information
Symbol
Dmel\Dlic2
Species
D. melanogaster
Name
FlyBase ID
FBal0269035
Feature type
allele
Associated gene
Dmel\Dlic
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Satoh et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: Y241term.

(Satoh et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,161,821..11,161,821 [+]
Nucleotide change:

T11161821A

Reported nucleotide change:

T?A

Amino acid change:

Y241term | Dlic-PA; Y146term | Dlic-PB; Y241term | Dlic-PD

Reported amino acid change:

Y241term

(Satoh et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The terminal cells in Dlic2 mutant trachea have thin cytoplasmic branches that lack air filling. Seamless tubes do not extend into these branches, although acetylated microtubules often do. Formation of filopodia at branch tips is disrupted and ectopic seamless tubes that are not air filled are detected near the nucleus. Discontinuous apical membrane fragments are found in terminal branches lacking seamless tubes and are associated with microtubule tracts.

      (Schottenfeld-Roames and Ghabrial, 2012)

      Dlic1/Dlic2 or Dlic2/Df(1)v-N48 dendrites of class IV da neurons at 44-48 hr after egg laying show a significant undergrowth phenotype. Dlic2/Dlic2 clones show an undergrowth phenotype in ddaC neurons.

      (Satoh et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Dlic2 has terminal tracheal cell phenotype, non-enhanceable by wkd220/Df(3R)Exel6276

      (Schottenfeld-Roames and Ghabrial, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wkd220/Df(3R)Exel6276 does not enhance the ectopic seamless tube phenotype seen in Dlic2 mutant tracheal terminal cells.

      (Schottenfeld-Roames and Ghabrial, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dlic2
      dlic2
      (Schottenfeld-Roames and Ghabrial, 2012, Satoh et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)