FlyBase Allele Report: Dmel\krz[UAS.Tag:GS-TAP]

General Information

Symbol

Dmel\krz^{UAS.Tag:GS-TAP}

Species

D. melanogaster

Name

FlyBase ID

FBal0247641

Feature type

allele

Associated gene

Dmel\krz

Associated Insertion(s)

Carried in Construct

P{UAS-krz.GS.NTAP}

Key Links

Transgenic product class

wild_type

(Kyriakakis et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kyriakakis et al., 2008)

Mutagen

in vitro construct

(Kyriakakis et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-krz.GS.NTAP}

Cytology

Description

UAS regulatory sequences drive expression of krz tagged with Tag:GS-TAP at the amino terminal.

(Kyriakakis et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

krz

Tagged with

Tag:GS-TAP

purification tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

krz^{UAS.Tag:GS-TAP}/Scer\GAL4^da.G32 is a suppressor of visible phenotype of Scer\GAL4^da.G32, krz^S047819/krz[+], rl^Sem.S.UAS

(Tipping et al., 2010)

krz^{UAS.Tag:GS-TAP}/Scer\GAL4^da.G32 is a suppressor of partially lethal - majority die phenotype of Scer\GAL4^da.G32, krz^S047819/krz[+], rl^Sem.S.UAS

(Tipping et al., 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

krz^{UAS.Tag:GS-TAP}/Scer\GAL4^da.G32 is a suppressor of wing vein phenotype of Scer\GAL4^da.G32, krz^S047819/krz[+], rl^Sem.S.UAS

(Tipping et al., 2010)

krz^{UAS.Tag:GS-TAP}/Scer\GAL4^da.G32 is a suppressor of eye phenotype of Scer\GAL4^da.G32, krz^S047819/krz[+], rl^Sem.S.UAS

(Tipping et al., 2010)

NOT Suppressor of

Statement

Reference

krz^{UAS.Tag:GS-TAP}/Scer\GAL4^da.G32 is a non-suppressor of wing phenotype of Scer\GAL4^da.G32, krz^S047819/krz[+], rl^Sem.S.UAS

(Tipping et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of rl^{Sem.S.Scer\UAS} and krz^{Scer\UAS.T:Zzzz\GS-TAP} under the control of Scer\GAL4^da.G32 in a krz^S047819/+ mutant background restores the wing vein phenotype to that seen in animals expressing just rl^{Sem.S.Scer\UAS} under the control of Scer\GAL4^da.G32 in a wild-type background. Wing size is larger in these flies compared to animals expressing rl^{Sem.S.Scer\UAS} under the control of Scer\GAL4^da.G32 in a wild-type background.

Expression of krz^{Scer\UAS.T:Zzzz\GS-TAP} restores the regular ommatidial pattern and size of the eye in animals expressing rl^{Sem.S.Scer\UAS} under the control of Scer\GAL4^da.G32 in a krz^S047819/+ mutant background.

The survival rate of animals expressing rl^{Sem.S.Scer\UAS} under the control of Scer\GAL4^da.G32 in a krz^S047819/+ mutant background increases to 38% when krz^{Scer\UAS.T:Zzzz\GS-TAP} is co-expressed.

(Tipping et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

krz^{UAS.Tag:GS-TAP}/Scer\GAL4^da.G32 rescues krz^S047819

(Kyriakakis et al., 2008)

Comments

Expression of krz^{Scer\UAS.T:Zzzz\GS-TAP} under the control of Scer\GAL4^da.G32 in a krz^S047819 mutant background completely rescues lethality.

(Kyriakakis et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

krz^{Scer\UAS.T:Zzzz\GS-TAP}

krz^{UAS.Tag:GS-TAP}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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