FlyBase Allele Report: Dmel\twf[102]

General Information

Symbol

Dmel\twf¹⁰²

Species

D. melanogaster

Name

FlyBase ID

FBal0247645

Feature type

allele

Associated gene

Dmel\twf

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Wang et al., 2010)

Progenitor genotype

P{EP}twf^EP3701

(Wang et al., 2010)

Cytology

Description

Imprecise excision of the progenitor insertion, P{EP}twf^EP3701, removing most of the coding region of twf.

(Wang et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Wang et al., 2010)

abnormal neuroanatomy (with Df(3R)su(Hw)7)

(Wang et al., 2010)

abnormal neuroanatomy (with twf¹¹⁰)

(Wang et al., 2010)

lethal - all die before end of larval stage

(Wang et al., 2010)

lethal - all die before end of larval stage (with twf¹¹⁰)

(Wang et al., 2010)

some die during larval stage

(Wang et al., 2010)

some die during larval stage (with twf¹¹⁰)

(Wang et al., 2010)

Phenotype Manifest In

adult mushroom body

(Wang et al., 2010)

adult mushroom body (with Df(3R)su(Hw)7)

(Wang et al., 2010)

adult mushroom body (with twf¹¹⁰)

(Wang et al., 2010)

adult mushroom body alpha-lobe

(Wang et al., 2010)

adult mushroom body beta-lobe

(Wang et al., 2010)

adult mushroom body beta-lobe (with Df(3R)su(Hw)7)

(Wang et al., 2010)

adult mushroom body beta-lobe (with twf¹¹⁰)

(Wang et al., 2010)

Detailed Description

Statement

Reference

The majority of twf¹¹⁰ mutant animals die as larvae. 1.8% of animals survive to adulthood.

The majority of twf¹¹⁰/twf¹⁰² mutant animals die as larvae. 2.2% of animals survive to adulthood.

β lobes of the mushroom body cross the midline in approximately 50% of twf¹⁰² and 30% of twf¹⁰²/Df(3R)su(Hw)7 mutant animal brains. In severe cases, the two β lobes are completely fused. β loves are bifurcated and thickened. 50% of twf^EP3701 mutants display unilateral or bilateral loss of the adult mushroom body α lobe.

β lobes of the mushroom body cross the midline in approximately 50% of twf¹¹⁰/twf¹⁰² mutant animal brains. In severe cases, the two β lobes are completely fused. β loves are bifurcated and thickened. 60% of twf^EP3701 mutants display unilateral or bilateral loss of the adult mushroom body α lobe.

(Wang et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34542

w^*; twf¹⁰²/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

twf¹⁰²

(Ogienko et al., 2018, Wang et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close