FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tkv1-A-T318D.UAS
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General Information
Symbol
Dmel\tkv1-A-T318D.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0247654
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{UAS-tkv.1-A-T318D}
Key Links
Transgenic product class
missense_variant
(Haerry, 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Haerry, 2010)
Mutagen
in vitro construct
(Haerry, 2010)
Progenitor genotype
Carried in construct
P{UAS-tkv.1-A-T318D}
Cytology
Description

UAS regulatory sequences drive expression of an activated form of tkv which carries a threonine to aspartic acid substitution at position 382.

(Haerry, 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tkv
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tkv1-A-T318D.Scer\UAS under the control of Scer\GAL4A9 results in a loss of longitudinal vein L4 and defects in L2 and L5.

      (Haerry, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4A9, tkv1-A-T318D.UAS has wing phenotype, enhanceable by Scer\GAL4A9/saxQ263D.UAS.Tag:HA

      (Haerry, 2010)

      Scer\GAL4A9, tkv1-A-T318D.UAS has wing phenotype, enhanceable by Scer\GAL4A9/saxA-K382D.UAS

      (Haerry, 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of saxQ263D.Scer\UAS.T:Ivir\HA1 in animals expressing tkv1-A-T318D.Scer\UAS under the control of Scer\GAL4A9 enhances the wing phenotype.

      Expression of saxA-K382D.Scer\UAS in animals expressing tkv1-A-T318D.Scer\UAS under the control of Scer\GAL4A9 enhances the wing phenotype.

      (Haerry, 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tkv1-A-T318D.Scer\UAS
      tkv1-A-T318D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)