FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mdr65Ex8
Open Close
General Information
Symbol
Dmel\Mdr65Ex8
Species
D. melanogaster
Name
FlyBase ID
FBal0247676
Feature type
allele
Associated gene
Dmel\Mdr65
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Mayer et al., 2009)
Progenitor genotype
Mdr65KG08723
(Mayer et al., 2009)
Cytology
Description

Imprecise excision of P{SUPor-P}Mdr65KG08723 removes some of the Mdr65 coding sequence around exon 8.

(Mayer et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Co-injection of TRD and B-Prz into wild-type and Mdr65Ex8 flies (in a w[-] background) confirms that the loss of Mdr65 in Mdr65Ex8 mutants leads to increased levels of B-Prz in both the brain and retina but leaves the paracellular diffusion barrier intact.

      Mdr65Ex8 mutants increase the sensitivity of SPG cells to vinblastine.

      (Mayer et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Mdr65Ex8 is rescued by Mdr65G1190D.UAS.GFP/Scer\GAL4moody.SPG

      (Mayer et al., 2009)
      Comments

      Expression of Mdr65G1190D.Scer\UAS.T:Avic\GFP at the humoral interface under the control of Scer\GAL4SPG is sufficient to restore efflux transport of small-molecule fluors, indicating that a role of Mdr65 in CNS protections is localized to the SPG.

      (Mayer et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ex8
      (Mayer et al., 2009)
      Mdr65Ex8
      Name Synonyms
      Secondary FlyBase IDs
        References (1)