Expressing foxo^HMS00422 under the control of Scer\GAL4^ppk.PU results in a significantly reduced number of branch points in the dendrites of class IV dendritic arborizing neurons in third instar larvae compared to wild-type controls.

Third instar larvae expressing foxo^HMS00422 under the control of Scer\GAL4^109(2)80 are significantly less motile and show more frequent head turning than wild-type controls.

The expression of foxo^HMS00422 under the control of Scer\GAL4^GMR58E02 leads to a significant decrease in the number of dopaminergic PAM neurons in the adult brain, as compared to controls; adulthood-only expression under the control of Scer\GAL4^Fer2.2359 (and Gal80[ts], for the temporal control of expression) also leads to a significant decrease in the number of dopaminergic PAM neurons in 35 days old adults, but not in 1 and 14 days old adults, as compared to controls.

Expression of foxo^HMS00422 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls.

Expression of foxo^HMS00422 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC neurons.

Third instar larvae expressing foxo^HMS00422 under the control of Scer\GAL4^D42 exhibit significantly elevated numbers of closed, tightly bundled futsch-positive microtubules at neuromuscular junction 6/7.