FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\crbΔFBM
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General Information
Symbol
Dmel\crbΔFBM
Species
D. melanogaster
Name
FlyBase ID
FBal0248411
Feature type
allele
Associated gene
Dmel\crb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Ling et al., 2010)
Progenitor genotype
crbGX24w-
(Ling et al., 2010)
Cytology
Description

Knock-in allele generated by phiC31-mediated integration at a founder knockout line containing a phiC31\attP site (crbGX24w-). Carries amino acid substitutions Y10A P12A E16A in the FERM-binding (FBM) motif of crb .

(Ling et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      crbΔFBM eye clones show a decrease in the ratio of pale vs yellow photoreceptor cells R8.

      (Pojer et al., 2021)

      No mitotic segregation defects are seen in crbΔFBM mutant embryos.

      (Yeom et al., 2015)

      Adult wings composed of predominantly homozygous crbΔFBM mutant cells are larger than normal.

      (Ling et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      crbΔFBM has rhabdomere | somatic clone - tissue specific phenotype, suppressible by kibra4/kibra4

      (Pojer et al., 2021)
      NOT Suppressor of
      Statement
      Reference

      crbΔFBM/crbΔFBM is a non-suppressor of rhabdomere | somatic clone - tissue specific phenotype of kibra4

      (Pojer et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      crbY10AP12AE16A
      (Ling et al., 2010)
      crbΔFBM
      (Pojer et al., 2021, Aguilar-Aragon et al., 2020, Su et al., 2017, Yeom et al., 2015, Ling et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)