FB2026_02 , released June 18, 2026
Allele: Dmel\wrdKO2
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General Information
Symbol
Dmel\wrdKO2
Species
D. melanogaster
Name
FlyBase ID
FBal0248458
Feature type
allele
Associated gene
Dmel\wrd
Associated Insertion(s)
TI{TI}wrdKO2
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
site specific recombination
(Hahn et al., 2010)
ends-out gene targeting
(Hahn et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}wrdKO2
Cytology
Description

The first exon of wrd has been replaced by a w+mW.hs marker flanked by loxP sites. This results in a shift in the reading frame of the remaining exons.

(Hahn et al., 2010)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wrdKO2/wrdKO2 larvae have similar fat content and accumulation of lipid droplets in oenocytes compared to controls.

      (Fischer et al., 2016)

      PP2A-B'KO2 mutant animals are lean compared to wild-type flies. Survival rates of PP2A-B'KO2 mutant flies is increased by feeding flies on diluted, less-rich, fly food (20% composition compared to regular fly food media), a condition which reduces the viability of wild-type controls.

      (Hahn et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      wrdKO2/wrdKO2 is a non-enhancer of decreased body size | adult stage phenotype of CycGHR7

      (Fischer et al., 2016)
      NOT Suppressor of
      Statement
      Reference

      wrdKO2/wrdKO2 is a non-suppressor of decreased body size | adult stage phenotype of CycGHR7

      (Fischer et al., 2016)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      wrdKO2/wrdKO2 is a suppressor of embryonic/larval oenocyte phenotype of CycGHR7

      (Fischer et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PP2A-B'KO2
      (Hahn et al., 2010)
      wrdKO2
      wrdko2
      (Fischer et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)