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General Information
Symbol
Dmel\stet1A3
Species
D. melanogaster
Name
FlyBase ID
FBal0248860
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A deletion allele resulting from the imprecise excision of a P-element. The deleted region includes that part of stet which encodes a seven transmembrane domain believed to be necessary for enzymatic activity.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

stet1A3 homozygotes are viable but sterile.

Germaria from stet1A3 mutant animals exhibit supernumerary spectrosome-containing cells. Virtually identical phenotypes are observed when stet function is specifically removed from the germ line. Germaria with a single stet1A3 mutant germline stem cell clone exhibit non-cell autonomous defects regarding supernumerary spectrosome-containing cells.

stet1A3 mutant germaria have similar numbers of cap cells as wild-type ones.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The supernumerary spectrosome-containing cell phenotype of stet1A3 mutants is suppressed by Krns.Scer\UAS.T:Hsap\MYC expression driven by Scer\GAL4nos.PU.

The supernumerary spectrosome-containing cell phenotype of stet1A3 mutants is partially suppressed by phlScer\UAS.F179 expression driven by Scer\GAL4C587.

tkvP906/+ suppresses the formation of ectopic spectrosome-containing cells in stet1A3 mutant germaria.

dpphr56/+ suppresses the formation of ectopic spectrosome-containing cells in stet1A3 mutant germaria.

Expression of dlpVDRC.cUa driven by Scer\GAL4unspecified in escort stem cells and escort cells fails to suppresses the supernumerary spectrosome-containing cell phenotype in stet1A3 mutant germaria.

Expression of dallyGD5918 driven by Scer\GAL4unspecified in escort stem cells and escort cells partially suppresses the supernumerary spectrosome-containing cell phenotype in stet1A3 mutant germaria.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

stet1A3 is partially rescued by stetbam.PL

Comments

The female sterility and the supernumerary spectrosome-containing cell phenotype of stet1A3 mutants is rescued by the expression of stetScer\UAS.P\T.cGa driven by Scer\GAL4nos.PU in the germ line.

stetbam.PL largely reverts the supernumerary spectrosome-containing cell phenotype and rescues the female sterility of stet1A3 mutants. However, many stet1A3 mutant germaria still have more spectrosome-containing cells than their wild-type counterparts.

The supernumerary spectrosome-containing cell phenotype of stet1A3 mutants is partially reverted by the expression of stetScer\UAS.P\T.cGa driven by Scer\GAL4bam.T:Hsim\VP16.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)