FB2025_05 , released December 11, 2025
Allele: Dmel\LnkDel29
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General Information
Symbol
Dmel\LnkDel29
Species
D. melanogaster
Name
FlyBase ID
FBal0248898
Feature type
allele
Associated gene
Dmel\Lnk
Associated Insertion(s)
PBac{RB5.WH5}LnkDel29
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Slack et al., 2010)
Mutagen
FLPase
(Slack et al., 2010)
Progenitor genotype
PBac{RB}e01414
(Slack et al., 2010)
PBac{WH}Lnkf02642
(Slack et al., 2010)
Associated Insertion(s)
PBac{RB5.WH5}LnkDel29
Cytology
Description

Recombination between the two progenitor insertions has deleted the sequence between them, removing the first two exons of Lnk, including the predicted translation start site.

(Slack et al., 2010)
Allele components
Component
Use(s)
Inserted element
PBac{RB5.WH5}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:25,887,914..25,890,390 [+]
(Slack et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      LnkDel29 female flies show significantly reduced re-mating rate 24 hours after mating to wild-type flies, compared to controls.

      (Wigby et al., 2011)

      Homozygotes show a 16% reduction in wing area and a 34% reduction in body mass compared to wild-type controls. The mean number of cells per wing and the mean cell size in the wing are both reduced in the mutant flies. A significant increase in both median and maximum lifespan is seen in both homozygous males and females compared to controls. Homozygous females are almost sterile, producing almost no eggs. Wild-type females mated to homozygous males produce normal numbers of offspring.

      Homozygous males and females show a significantly increased median survival when fed 5% hydrogen peroxide compared to control flies.

      Homozygous males and females show a significantly increased survival under starvation conditions compared to control flies.

      Homozygous males and females show a significant increase in whole body triglyceride, glycogen and trehalose levels compared to controls.

      Lnkd07478/LnkDel29 animals show a 16% reduction in wing area and a 34% reduction in body mass compared to wild-type controls.

      LnkDel29/Df(3R)Espl3 animals show a 19% reduction in wing area and a 35% reduction in body mass compared to wild-type controls.

      (Slack et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      LnkDel29, foxoΔ94 has lethal phenotype

      (Slack et al., 2011)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      LnkDel29 is rescued by Lnk+t6

      (Slack et al., 2010)
      Comments

      The reduction in wing area an in body mass which is seen in LnkDel29 flies is fully rescued by Lnk+t6. The increased lifespan seen in homozygous LnkDel29 females is restored to normal by Lnk+t6. Lnk+t6 restores the number of eggs laid by homozygous LnkDel29 females to wild-type levels. Lnk+t6 restores the increased resistance of homozygous LnkDel29 flies to 5% hydrogen peroxide and to starvation to wild-type levels. Lnk+t6 restores the increased levels of whole body triglyceride, glycogen and trehalose that are seen in LnkDel29 flies to wild-type levels.

      (Slack et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      LnkDel29
      (Slack et al., 2011, Wigby et al., 2011, Slack et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)