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General Information
Symbol
Dmel\LnkDel29
Species
D. melanogaster
Name
FlyBase ID
FBal0248898
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Recombination between the two progenitor insertions has deleted the sequence between them, removing the first two exons of Lnk, including the predicted translation start site.

Insertion components
PBac{RB5.WH5}LnkDel29
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

LnkDel29 female flies show significantly reduced re-mating rate 24 hours after mating to wild-type flies, compared to controls.

Homozygotes show a 16% reduction in wing area and a 34% reduction in body mass compared to wild-type controls. The mean number of cells per wing and the mean cell size in the wing are both reduced in the mutant flies. A significant increase in both median and maximum lifespan is seen in both homozygous males and females compared to controls. Homozygous females are almost sterile, producing almost no eggs. Wild-type females mated to homozygous males produce normal numbers of offspring.

Homozygous males and females show a significantly increased median survival when fed 5% hydrogen peroxide compared to control flies.

Homozygous males and females show a significantly increased survival under starvation conditions compared to control flies.

Homozygous males and females show a significant increase in whole body triglyceride, glycogen and trehalose levels compared to controls.

Lnkd07478/LnkDel29 animals show a 16% reduction in wing area and a 34% reduction in body mass compared to wild-type controls.

LnkDel29/Df(3R)Espl3 animals show a 19% reduction in wing area and a 35% reduction in body mass compared to wild-type controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

The reduction in wing area an in body mass which is seen in LnkDel29 flies is fully rescued by Lnk+t6. The increased lifespan seen in homozygous LnkDel29 females is restored to normal by Lnk+t6. Lnk+t6 restores the number of eggs laid by homozygous LnkDel29 females to wild-type levels. Lnk+t6 restores the increased resistance of homozygous LnkDel29 flies to 5% hydrogen peroxide and to starvation to wild-type levels. Lnk+t6 restores the increased levels of whole body triglyceride, glycogen and trehalose that are seen in LnkDel29 flies to wild-type levels.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)