FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lnkd07478
Open Close
General Information
Symbol
Dmel\Lnkd07478
Species
D. melanogaster
Name
FlyBase ID
FBal0160237
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Insertion within the first intron.

Allele components
Component
Use(s)
Mutations Mapped to the Genome
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Egg chambers arrest in early vitellogenesis in mutant females.

Homozygotes show a 20% reduction in wing area and a 42% reduction in body mass compared to wild-type controls. The mean number of cells per wing and the mean cell size in the wing are both reduced in the mutant flies. A significant increase in both median and maximum lifespan is seen in both homozygous males and females compared to controls. Homozygous females produce significantly fewer eggs compared to wild-type females. Wild-type females mated to homozygous males produce normal numbers of offspring.

Lnkd07478/LnkDel29 animals show a 16% reduction in wing area and a 34% reduction in body mass compared to wild-type controls.

Body length is decreased by 11% compared to controls in homozygous third instar larvae and body weight is decreased by 21% in homozygous adults. Homozygous adults have wings that are reduced in size as compared to controls, due to a decrease both in the size and number of cells.

Total triglycerides are increased by 92% in the fat bodies of homozygous adults compared to those of control wild-type animals. Hemolymph trehalose levels are increased by 37% in homozygous flies compared to controls. Whole body trehalose and total sugar levels are increased by 102% and 85% respectively in homozygous flies compared to controls.

Homozygous and Lnkd07478/Lnkf02642 files show increased survival under starvation conditions compared to wild type.

Homozygotes show an increase in lifespan compared to control; the median lifespan is increased by 14% in male and 33% in female flies, while the maximal lifespan is increased by 14% in male and 15% in female flies.

Homozygotes show increased resistance to paraquat compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The ventralisation phenotype seen in eggs laid by spn-BBU females is suppressed if the females are also mutant for LnkCR642/Lnkd07478.

The ventralisation phenotype seen in eggs laid by spn-A093A/spn-A1 females is suppressed if the females are also mutant for LnkCR642/Lnkd07478.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)