FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nmdar1UAS.cMa
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General Information
Symbol
Dmel\Nmdar1UAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Miyashita
FlyBase ID
FBal0248911
Feature type
allele
Associated gene
Dmel\Nmdar1
Associated Insertion(s)
Carried in Construct
P{UAS-Nmdar1.M}
Key Links
Transgenic product class
wild_type
(Tamura et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tamura et al., 2010)
Mutagen
in vitro construct
(Tamura et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Nmdar1.M}
Cytology
Description

UAS regulatory sequences drive expression of full length Nmdar1.

(Tamura et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nmdar1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Renpenning syndrome
      modeled by PQBP1PL00109
      (Tamura et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Nmdar1Scer\UAS.cMa under the control of Scer\GAL4elav.PU show normal learning (memory measured immediately after conditioning) and short-term memory (assayed 1 hour after training) in an aversive olfactory conditioning assay. One-day memory after spaced training (long-term memory) and one-day memory after massed training (anesthesia-resistant memory) are normal.

      Acute expression of Nmdar1Scer\UAS.cMa under the control of Scer\GAL4elav.Switch.PO (by feeding 1mM RU486 starting one day prior to training) has no effect on one-day long term memory.

      (Miyashita et al., 2012)

      Expression of Nmdar1Scer\UAS.cMa under the control of either Scer\GAL4GH146 or Scer\GAL4NP0225 in a wild-type background does not increase learning acquisition.

      (Tamura et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Nmdar1Scer\UAS.cMa under the control of Scer\GAL4elav.PLu rescues the shortened lifespan of PQBP1PL00109 flies.

      (Tamura et al., 2013)

      The learning defects of PQBP1PL00109 flies are rescued by expression of Nmdar1Scer\UAS.cMa under the control of Scer\GAL4PQBP1-PL00109.

      (Tamura et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/Nmdar1UAS.cMa rescues Nmdar1EP331

      (Miyashita et al., 2012)
      Comments

      Expression of Nmdar1Scer\UAS.cMa under the control of Scer\GAL4elav.PU rescues the learning defects seen in Nmdar1EP331 flies.

      (Miyashita et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Nmdar1Scer\UAS.cMa
      Nmdar1UAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Miyashita
      Secondary FlyBase IDs
        References (5)