FB2026_02 , released June 18, 2026
Allele: Dmel\htsUAS.Add1.Tag:MYC
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General Information
Symbol
Dmel\htsUAS.Add1.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0248992
Feature type
allele
Associated gene
Dmel\hts
Associated Insertion(s)
Carried in Construct
P{UAS-hts.Add1.myc}
Key Links
Transgenic product class
cDNA
(Ohler et al., 2011)
wild_type
(Ohler et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ohler et al., 2011)
wild_type
(Ohler et al., 2011)
Mutagen
in vitro construct
(Ohler et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-hts.Add1.myc}
Cytology
Description

UAS drives expression of a cDNA encoding the 718 aa 'Add1' isoform of the hts product. (In addition to the common first 472 N-terminal amino acids, 'Add1' contains the Adducin tail including the MARCKS domain.) There is a 4x Tag:MYC at the C-terminus.

(Ohler et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
hts
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When htsScer\UAS.Add1.T:Hsap\MYC is expressed using Scer\GAL4GMR.PU, the medulla looks normal overall. However, R8 axons show abnormally thick swellings at the M1 layer.

      (Ohler et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      R8 axon swelling seen in Scer\GAL4GMR.PU, gogoScer\UAS.T1 animals is suppressed when htsScer\UAS.Add1.T:Hsap\MYC is co-expressed. Likewise, the R8 axon swelling seen in Scer\GAL4GMR.PU, htsScer\UAS.Add1.T:Hsap\MYC animals is suppressed when gogoScer\UAS.T1 is co-expressed.

      (Ohler et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      htsScer\UAS.Add1.T:Hsap\MYC
      htsUAS.Add1.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)