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General Information
Symbol
Dmel\ImpL2s.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0249386
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-s.ImpL2, UAS-sImp-L2
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of ImpL2 lacking the first exon (containing three upstream open reading frames) of the ImpL2-RB transcript.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ImpL2s.Scer\UAS in the hindgut under the control of Scer\GAL4byn.n2 results in a substantial reduction in ovarian size, which is accompanied by apoptotic egg chambers, loss of mature eggs, and reduced fertility. Hindgut driven ImpL2s.Scer\UAS-expression also reduces fat body size and induces lipid droplet enlargement.

Overexpression of ImpL2s.Scer\UAS under the control of Scer\GAL4da.Switch.PT significantly extends the lifespan compared to control flies.

Ubiquitous overexpression of ImpL2s.Scer\UAS under the control of Scer\GAL4Act5C.PI leads to lethality.

Ubiquitous overexpression of ImpL2s.Scer\UAS under the control of Scer\GAL4arm.PS leads to lethality.

Overexpression of ImpL2s.Scer\UAS driven by Scer\GAL4GMR.PF results in a strong reduction of eye size. The body weight of ImpL2s.Scer\UAS-overexpressing flies is reduced compared with controls. The development of Scer\GAL4GMR.PF-driven ImpL2s.Scer\UAS-overexpressing males is delayed by one day.

Driving ImpL2s.Scer\UAS by Scer\GAL4ppl.PP results in lethality.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

ImpL2s.Scer\UAS completely reverses the eye overgrowth resulting from the overexpression of InRScer\UAS.cHa driven by Scer\GAL4GMR.PF.

Co-expression of Ilp2Scer\UAS.cBa with ImpL2s.Scer\UAS under the control of Scer\GAL4ppl.PP suppresses the lethality caused by the overexpression of the individual Ilp2Scer\UAS.cBa or ImpL2s.Scer\UAS transgenes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ImpL2s.Scer\UAS
ImpL2s.UAS
Name Synonyms
Secondary FlyBase IDs
    References (9)