FlyBase Allele Report: Scer\GAL4[GMR42H07]

General Information

Symbol

Scer\GAL4^GMR42H07

Species

S. cerevisiae

Name

FlyBase ID

FBal0252468

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{GMR42H07-GAL4}

Also Known As

R42H07-GAL4, R42H07

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Pfeiffer et al., 2011.2.9)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{GMR42H07-GAL4}

Cytology

Nature of the lesion

Statement

Reference

A 4476 base pair fragment from the flanking non-coding or intronic region of Sox102F is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)

Allele components

Product class / Tool use(s)

Encoded product / tool

GAL4

binary expression system - driver

Associated Sequence Features

GMR42H07

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

T neuron T5

(Maisak et al., 2013)

I2 motor neuron

(O'Sullivan et al., 2018)

Additional Information

Statement

Reference

Expression driven by Scer\GAL4^GMR42H07 is detected in four distinct layers of the lobula plate, representing the terminal arborizations of T5 cells.

(Maisak et al., 2013)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Ctet\tetX^TNT-LC.UAS

(O'Sullivan et al., 2018)

abnormal flight | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(O'Sullivan et al., 2018)

abnormal neurophysiology, with Ctet\tetX^TNT-LC.UAS

(Maisak et al., 2013)

abnormal song, with Ctet\tetX^TNT-LC.UAS

(O'Sullivan et al., 2018)

Phenotype Manifest In

lobula plate, with Ctet\tetX^TNT-LC.UAS

(Maisak et al., 2013)

Detailed Description

Statement

Reference

Silencing (using Ctet\TeTxLC^TNT.UAS) of Scer\GAL4^GMR42H07 neurons in adult males significantly alters some parameters of pulse song, but not sine song, compared to controls; there is no significant effect on the number of males that sing, wing extension toward females, or copulation success, compared to controls; forced flight ability, but not take off ability, is significantly impaired, compared to controls.

Optogenetic activation (using Cnoc\ChR1^{Cs.IVS.20xUAS.Venus} with 590 nm (yellow) light) of Scer\GAL4^GMR42H07 neurons in adult males during flight results in either flight stopping or a significant reduction in wing beat amplitude.

(O'Sullivan et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

50172

w¹¹¹⁸; P{GMR42H07-GAL4}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^GMR42H07

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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