FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4GMR52F05
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General Information
Symbol
Scer\GAL4GMR52F05
Species
S. cerevisiae
Name
FlyBase ID
FBal0253309
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR52F05-GAL4}
Also Known As
R52F05, R52F05-GAL4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR52F05-GAL4}
Cytology
Description

A 832 base pair fragment from the flanking non-coding or intronic region of Nos is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR52F05
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      antennal mechanosensory and motor center local AMMC-AMMC 1 neuron
      (Matsuo et al., 2016, Vaughan et al., 2014)
      adult gnathal ganglion | restricted
      (Vaughan et al., 2014)
      adult ventral nerve cord | restricted
      (Vaughan et al., 2014)
      abdominal nerve | restricted
      (Vaughan et al., 2014)
      Additional Information
      Statement
      Reference

      ScerGAL4GMR52F05 drives expression mainly in antennal mechanosensory and motor center local AMMC-AMMC 1 neuron, but also drives expression in approximately six cells in the gnathal ganglion and several lineages within the terminal abdominal nerve.

      (Vaughan et al., 2014)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Ctet\tetXTNT-LC.UAS) of Scer\GAL4GMR52F05 cells significantly reduces larval escape behavior in response to HCl application, compared to controls.

      (Lopez-Bellido et al., 2019)

      Optogenetic activation (using Crei\ChR1::Vcar\ChR1::Vcar\ChR2ReaChR.UAS.Citrine with 617 nm (red) light) of Scer\GAL4GMR52F05 cells in larvae results in significant induction of nociceptive rolling behavior in the absence of nociceptive stimuli, compared to controls; this no longer occurs when activation is restricted to a smaller subset of Scer\GAL4GMR52F05 cells using Ecol\lexAGMR94B10 and Scer\GAL80IVS.WPRE.8xlexAop.

      (Yoshino et al., 2017)

      Inhibition (using shi1.UAS at 30[o]C) of Scer\GAL4GMR52F05 neurons in adult females does not significantly affect receptivity to mating, compared to controls; in males, courtship pulse song-induced locomotion is not significantly affected, compared to controls.

      Thermogenetic activation (using TrpA1UAS.(B).cKa at 27[o]C) of Scer\GAL4GMR52F05 neurons in adult females does not significantly affect receptivity to mating, compared to controls.

      (Vaughan et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR52F05
      Name Synonyms
      Secondary FlyBase IDs
        References (7)