FlyBase Allele Report: Dmel\Gr61a[1]

General Information

Symbol

Dmel\Gr61a¹

Species

D. melanogaster

Name

FlyBase ID

FBal0256895

Feature type

allele

Associated gene

Dmel\Gr61a

Associated Insertion(s)

Carried in Construct

Also Known As

ΔGr61a, Δ61a

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dahanukar et al., 2007)

Progenitor genotype

P{EP}G4277

(Dahanukar et al., 2007)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of the Gr61a gene.

(Dahanukar et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal taste perception

(Freeman et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Gr61a¹ mutants exhibit a statistically significant reduction in the response to trehalose, melezitose, m-glucoside, and glucose. However, responses to sucrose, maltose, maltotriose, fructose and glycerol are unaffected.

(Freeman et al., 2014)

Gr61a¹ Gr5a^LEXA Df(3L)ΔGr64 mutants expressing P{t15.3.R1} and P{UAS-Rescue.R2} (i.e. lacking all 8 sweet gustatory receptor genes) do not exhibit any defects in fructose preference in two-choice preference assays.

(Mishra et al., 2013)

Electrophysiological recordings of the L-type labellar sensilla of mutant flies in response to a number of sugars are very similar to those of control flies.

(Dahanukar et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Df(3L)ΔGr64, Gr61a¹ has abnormal proboscis extension reflex phenotype, enhanceable by Gr43a^GAL4

(Miyamoto et al., 2012)

Suppressed by

Statement

Reference

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr61a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr61a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, suppressible | partially by Gr5a^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, suppressible | partially by Gr5a^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

NOT suppressed by

Statement

Reference

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Gr64c^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Gr64c^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Gr64f^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Gr64f^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Other

Statement

Reference

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal oviposition | chemical conditional phenotype

(Wu et al., 2019)

Df(3L)ΔGr64/Gr64f^LEXA, Gr5a[+]/Gr5a^LEXA, Gr61a¹ has abnormal oviposition | chemical conditional phenotype

(Wu et al., 2019)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal chemosensory behavior | adult stage phenotype

(Ahn et al., 2017)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal proboscis extension reflex phenotype

(Ahn et al., 2017)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal neurophysiology | adult stage phenotype

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has abnormal taste perception | adult stage phenotype

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr61a¹ has abnormal proboscis extension reflex phenotype

(Miyamoto et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr61a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, suppressible | partially by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, suppressible | partially by Gr5a^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

NOT suppressed by

Statement

Reference

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Gr64c^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Gr64c^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Gr64f^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Gr64f^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Gr64d^UAS.cUa/Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr61a^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64b^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype, non-suppressible by Scer\GAL4^Gr61a.4.9/Gr64a^UAS.cUa/Gr64e^UAS.cUa

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype, non-suppressible by Gr5a^UAS.cUa/Scer\GAL4^Gr61a.4.9

(Yavuz et al., 2014)

Other

Statement

Reference

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5b phenotype

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr5a^LEXA, Gr61a¹ has sugar-sensing neuron of prothoracic leg tarsal taste bristle 5v phenotype

(Yavuz et al., 2014)

Df(3L)ΔGr64, Gr43a^GAL4, Gr61a¹ has prothoracic leg taste bristle chemosensory neuron phenotype

(Miyamoto et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Adult females homozygous for Gr5a^LEXA, Gr61a¹ and Df(3L)ΔGr64, or with Gr5a^LEXA/+, Gr61a¹/+ and Gr64f^LEXA/Df(3L)ΔGr64, have a significant increase in preference for softer 100 mM sucrose-containing, but not plain, agarose for egg laying, compared to controls; these mutants also have a significant reduction in preference for 100 mM sucrose-containing (rather than plain) agarose for egg laying, compared to controls.

(Wu et al., 2019)

Adults with homozygous Gr5a^LEXA, Gr61a¹ and Df(3L)ΔGr64 have proboscis extension rates that are significantly reduced in response to sucrose and significantly increased in response to some fatty acids, compared to controls.

(Ahn et al., 2017)

Gr5a^LEXA, Gr61a¹, Df(3L)ΔGr64 triple homozygotes that also bear P{t15.3.R1} (P{t15.3.R1} rescues the lethality of Df(3L)ΔGr64 homozygosity) have impaired responsiveness to sweet chemical: sweet taste 5b sensilla GRNs virtually lack the expected responsiveness to the chemicals Sucrose, Fructose, Maltose, Trehalose, Glucose, Melezitose, Arabinose and Glycerol, as compared to controls; sweet taste 5v sensilla GRNs show the expected responsive only to Sucrose and Fructose, but lack responses to Maltose, Trehalose and Glucose.

Expressing Gr64a^UAS.cUa under the control of Scer\GAL4^Gr61a.4.9 restores the response of 5v sensilla GRNs only to Maltose but does not affect the responses of 5b sensilla GRNs.

Expressing Gr61a^UAS.cUa under the control of Scer\GAL4^Gr61a.4.9 restores a moderate response of 5v sensilla GRNs only to Glucose but does not affect the responses of 5b sensilla GRNs.

Expressing Gr5a^UAS.cUa under the control of Scer\GAL4^Gr61a.4.9 restores a small response of 5v sensilla GRNs only to Trehalose but does not affect the responses of 5b sensilla GRNs.

Co-expressing Gr64a^UAS.cUa and Gr64e^UAS.cUa under the control of Scer\GAL4^Gr61a.4.9 restores the response of 5b sensilla GRNs only to Maltose and Sucrose, but does not affect the responses by 5v sensilla GRNs.

Co-expressing Gr64b^UAS.cUa and Gr64e^UAS.cUa under the control of Scer\GAL4^Gr61a.4.9 restores the response of 5b sensilla GRNs only to Glycerol, but does not affect the responses by 5v sensilla GRNs.

(Yavuz et al., 2014)

The Ca[2+] response of taste neurons in the forelegs to fructose, sucrose, glucose, trehalose, arabinose or maltose is abolished in flies triply homozygous Gr43a^GAL4 ; Gr61a¹ Df(3L)ΔGr64.

Gr61a¹ Df(3L)ΔGr64 double mutant flies show a significantly reduced proboscis extension reflex to fructose and sucrose and fail to respond to glucose.

Gr43a^GAL4 ; Gr61a¹ Df(3L)ΔGr64 triple mutant flies show completely lack a proboscis extension reflex to fructose and sucrose.

(Miyamoto et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Gr61a^-

(Mishra et al., 2013)

Gr61a¹

(Shrestha et al., 2023, Freeman et al., 2014, Dahanukar et al., 2007)

Δ61a

(Guo et al., 2021, Wu et al., 2019, Yavuz et al., 2014)

ΔGr61a

(Chen et al., 2019, Devineni et al., 2019, Ahn et al., 2017, Yavuz et al., 2014, Miyamoto et al., 2012, Dahanukar et al., 2007)

ΔGr61a¹

(Kim et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (12)

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