FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-263bΔ-G4
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General Information
Symbol
Dmel\mir-263bΔ-G4
Species
D. melanogaster
Name
FlyBase ID
FBal0257045
Feature type
allele
Associated gene
Dmel\mir-263b
Associated Insertion(s)
TI{GAL4}mir-263bΔ-G4
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Hilgers et al., 2010)
gene targeting by homologous recombination
(Hilgers et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}mir-263bΔ-G4
Cytology
Description

Sequence encoding the mir-263b miRNA hairpin has been replaced by sequence encoding a GAL4 driver and a mini-w marker. This allows for expression of GAL4 coding region under the control of the endogenous mir-263b promoter.

(Hilgers et al., 2010)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mir-263bΔ/mir-263bΔ-G4 adults show decreased circadian rhythmicity and circadian power under constant dark, as compared to wild-type and mir-263bΔ-G4 heterozygous controls. mir-263bΔ/mir-263bΔ-G4 transheterozygous and mir-263bΔ-G4 heterozygous adults also exhibit a lack and decrease in morning anticipation activity, respectively.

      mir-263bΔ-G4 heterozygous adults do not show defects in the circadian plasticity of sLNv dorsal projections.

      (Nian et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Acute activation of Pdf-positive neurons by expressing TrpA1UAS.(B).cKa under the control of Scer\GAL4Pdf.PU and temperature shift to 30[o]C at ZT12 leads to increased complexity of sLNv dorsal projections at Z14; the same is observed in a mir-263bΔ/mir-263bΔ background.

      (Nian et al., 2019)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mir-263bΔ-G4
      Δ263b-G4
      (Hilgers et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)