FlyBase Allele Report: Dmel\Rpn11[HMS00071]

General Information

Symbol

Dmel\Rpn11^HMS00071

Species

D. melanogaster

Name

FlyBase ID

FBal0257103

Feature type

allele

Associated gene

Dmel\Rpn11

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00071}

Also Known As

UAS-Rpn11 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00071}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00071

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Kennedy's disease

modeled by Hsap\AR^Q52.UAS

(Nath et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | female, with Scer\GAL4^{VP16.mat.αTub67C}

(Zavortink et al., 2020)

lethal | larval stage, with Scer\GAL4^elav.PU

(Tsou et al., 2012)

lethal | pupal stage, with Scer\GAL4^elav.PU

(Tsou et al., 2012)

lethal - all die before end of larval stage, with Scer\GAL4^sqh.PW

(Tsou et al., 2012)

some die during larval stage, with Scer\GAL4^sqh.PW

(Tsou et al., 2012)

Phenotype Manifest In

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

mitochondrion | P-stage | absent, with Scer\GAL4^phtm.PU

(Zhang et al., 2025)

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

prothoracic gland | P-stage, with Scer\GAL4^phtm.PU

(Zhang et al., 2025)

Detailed Description

Statement

Reference

Expressing Rpn11^HMS00071 under the control of Scer\GAL4^Cg.PA leads to larval fat body mitochondria to appear fuzzy and clustered (as assessed by MitoGFP), although the morphology of individual mitochondria is relatively normal (as assessed by EM).

(Zhou et al., 2019)

Expression of Rpn11^HMS00071 using a relatively weak Scer\GAL4^elav.PU results in slower adults.

(Tsou et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33662

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00071}attP2

NIG-Fly

HMS00071

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00071}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rpn11^HMS00071

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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