FlyBase Allele Report: Dmel\CtBP[HMS00677]

General Information

Symbol

Dmel\CtBP^HMS00677

Species

D. melanogaster

Name

FlyBase ID

FBal0257360

Feature type

allele

Associated gene

Dmel\CtBP

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00677}

Also Known As

UAS-CtBP^RNAi, UAS-CtBP-IR

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00677}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00677

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of primary ovarian insufficiency

CEA

(Henarejos-Castillo et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Wu et al., 2021)

modeled by scrib^GD11663

(Wu et al., 2021)

modeled by Ras85D^V12.UAS, sna^UAS.cAa

(Wu et al., 2021)

modeled by sna^UAS.cAa

(Wu et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

(Kim et al., 2019)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

(Kim et al., 2019)

NMJ bouton | third instar larval stage, with Scer\GAL4^elav-C155

(Kim et al., 2019)

Detailed Description

Statement

Reference

Expressing CtBP^HMS00677 under the control of Scer\GAL4^elav-C155 results in supernumerary mature and satellite boutons at the NMJ in third instar larvae.

(Kim et al., 2019)

Expression of CtBP^HMS00677 under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) does not lead to ectopic wings compared to controls.

(Worley et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

CtBP^HMS00677, Scer\GAL4^elav-C155 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by wit^A12/wit[+]

(Kim et al., 2019)

Suppressor of

Statement

Reference

CtBP^HMS00677, Scer\GAL4^GMR.PU is a suppressor of decreased size | adult stage phenotype of Scer\GAL4^GMR.PU, Tgi^UAS.Tag:HA

(Vissers et al., 2020)

CtBP^HMS00677, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Tgi^UAS.Tag:HA

(Vissers et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/CtBP^HMS00677 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of wit^B11/wit^A12

(Kim et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

CtBP^HMS00677, Scer\GAL4^elav-C155 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by wit^A12/wit[+]

(Kim et al., 2019)

CtBP^HMS00677, Scer\GAL4^elav-C155 has NMJ bouton | third instar larval stage phenotype, suppressible by wit^A12/wit[+]

(Kim et al., 2019)

Suppressor of

Statement

Reference

CtBP^HMS00677, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Tgi^UAS.Tag:HA

(Vissers et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/CtBP^HMS00677 is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of wit^B11/wit^A12

(Kim et al., 2019)

Scer\GAL4^elav-C155/CtBP^HMS00677 is a non-suppressor of NMJ bouton | third instar larval stage phenotype of wit^B11/wit^A12

(Kim et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of CtBP^HMS00677 and egr^UAS.cUa under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) does not lead to ectopic wings compared to controls.

(Worley et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32889