FlyBase Allele Report: Dmel\Hrs[HMS00840]

General Information

Symbol

Dmel\Hrs^HMS00840

Species

D. melanogaster

Name

FlyBase ID

FBal0257520

Feature type

allele

Associated gene

Dmel\Hrs

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00840}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00840}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00840

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | pupal stage, with Scer\GAL4^ppk.1.9

(Loncle et al., 2015)

visible, with Scer\GAL4^ap-md544

(O'Farrell et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Hrs^HMS00840 under the control of Scer\GAL4^ap-md544 leads to adult wings presenting an upward curvature.

(O'Farrell et al., 2017)

Knockdown of Hrs^HMS00840 driven in the class IV dendritic arborizing sensory neuron ddaC by Scer\GAL4^ppk.1.9 leads to mild disruptions in pruning at 18hr after puparium formation, with minor delay and clearance defects.

(Loncle et al., 2015)

Intraluminal vesicles inside MVBs or lysosomes (MVBLs) are almost completely absent in male secondary cells expressing Hrs^HMS00840 under the control of Scer\GAL4^spi-NP0261. Maturing MVBLs (mMVBLs) are larger than controls. The number of immature late endosomes (iLEs) is similar to controls but the number of mMVBLs per secondary cell is reduced. Exosome secretion into the accessory lumen gland is reduced compared to controls when Hrs^HMS00840 is expressed under the control of Scer\GAL4^dsx.KI.

The nuclei of accessory gland secondary cells expressing Hrs^HMS00840 under the control of Scer\GAL4^esg-NP7397 are increased in size compared compared to neighbouring main cell nuclei.

(Corrigan et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^insc-Mz1407/Hrs^HMS00840 is a non-enhancer of increased cell number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Scer\GAL4^insc-Mz1407/Hrs^HMS00840 is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of Vps35^E42