FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Su(dx)UAS.cCa
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General Information
Symbol
Dmel\Su(dx)UAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Cornell
FlyBase ID
FBal0098290
Feature type
allele
Associated gene
Dmel\Su(dx)
Associated Insertion(s)
Carried in Construct
P{UAS-Su(dx).C}
Also Known As
UAS-Su(dx)
Key Links
Transgenic product class
wild_type
(Cornell et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Cornell et al., 1999)
Mutagen
in vitro construct
(Cornell et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-Su(dx).C}
Cytology
Description

Expression of Su(dx) is governed by UASt regulatory sequences.

(Cornell et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Su(dx)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  brain cancer
      modeled by Vps35E42
      (Li et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Coexpression of NdfipUAS.Tag:FLAG and Su(dx)UAS.cCa is required to rescue the brain tumor phenotype observed in Vps35E42 mutants .

      (Li et al., 2018)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Su(dx)Scer\UAS.cCa under the control of Scer\GAL4lz-gal4 results in significant decreases in both the number and size of third instar larval circulating crystal cells, as compared to controls.

      (Miller et al., 2017)

      Expression of Su(dx)Scer\UAS.cCa under the control of Scer\GAL4E(spl)m6-BFM.PF leads to significantly increased numbers of abdominal lateral adult muscle precursor cells in third instar larvae, as compared to controls.

      (Aradhya et al., 2015)

      Overexpression of Su(dx)Scer\UAS.cCa using Scer\GAL4ptc-559.1 results in a mild disruption of wing veins.

      Expression of Su(dx)Scer\UAS.cCa using Scer\GAL4ptc-559.1 results in significant mortality.

      Overexpression of Su(dx)Scer\UAS.cCa using Scer\GAL4Bx-MS1096 results in a mild wing phenotype, with vein thickening especially near the wing margins.

      (Dalton et al., 2011)

      Expression of Su(dx)Scer\UAS.cCa under the control of Scer\GAL4dpp.PU consistently results in an increased number of macrochaetae.

      (Djiane et al., 2011)

      Clones in the wing expressing Su(dx)Scer\UAS.cCa under the control of Scer\GAL4Act5C.PP result in ectopic vein material as well as wing margin loss. Expression of Su(dx)Scer\UAS.cCa under the control of Scer\GAL4ptc-559.1 at 29oC results in loss of the adult wing margin. Expression of Su(dx)Scer\UAS.cCa under the control of Scer\GAL4dpp.blk1 at 29oC results in truncated malformed legs, a thickened L3 wing vein and wing notches.

      (Wilkin et al., 2004)

      When Su(dx)Scer\UAS.cCa is driven by Scer\GAL4ptc-559.1 at 25oC tarsi are truncated and extra sex combs are seen. The joints in the tarsal segment are almost completely eliminated, though some residual joint material can be seen.

      (Mazaleyrat et al., 2003)

      When expression is driven by Scer\GAL4ptc-559.1, ectopic wing veins and wing margin loss are observed. The wing is broadened due to an increased number of cells between wing vein L3 and L4 (i.e. along the AP boundary). The effect is particularly noticeable proximally. When expression is driven by Scer\GAL4Bx-MS1096, ectopic wing veins occur but there is no effect on the wing margin.

      (Cornell et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expressing Su(dx)UAS.cCa and NdfipUAS.Tag:FLAG under the control of Scer\GAL4pnt-14-94 results in a decrease in type II neuroblast lineages in the larval brain, associated with brain atrophy.

      (Li et al., 2018)

      Co-expression of NdfipScer\UAS.T:Ivir\HA1 enhances the Su(dx)Scer\UAS.cCa, Scer\GAL4ptc-559.1 wing phenotype, with loss of the wing margin.

      Co-expression of NdfipScer\UAS.T:Ivir\HA1 enhances the Su(dx)Scer\UAS.cCa, Scer\GAL4Bx-MS1096 wing phenotype, resulting in a severely disrupted wing with increased vein thickening and smaller wing size.

      Wings discs that co-express Su(dx)Scer\UAS.cCa and NdfipScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Bx-MS1096 are undulated, unlike wild type.

      (Dalton et al., 2011)

      The increased number of dorsocentral macrochaetae in animals expressing Su(dx)Scer\UAS.cCa under the control of Scer\GAL4dpp.PU is enhanced in a pydex147/+ background.

      The increased number of dorsocentral macrochaetae in animals expressing Su(dx)Scer\UAS.cCa under the control of Scer\GAL4dpp.PU is enhanced by co-expression of pyddsRNA.Scer\UAS.

      (Djiane et al., 2011)

      Co-expression of Nedd4CA.Scer\UAS.T:Hsap\MYC rescues the leg, wing margin and wing vein phenotypes produced by expression of Su(dx)Scer\UAS.cCa under the control of Scer\GAL4dpp.blk1 and only a small amount of extra wing vein is still present in the rescued flies.

      (Wilkin et al., 2004)

      When expression is driven by Scer\GAL4Bx-MS1096 in a Df(1)N-54l9 background, wing vein thickening is enhanced. When expression is driven by Scer\GAL4Bx-MS1096 in a Dl171 background, wing vein thickening is enhanced.

      (Cornell et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Su(dx)UAS.cCa/Scer\GAL4Bx-MS1096 rescues Su(dx)32

      (Cornell et al., 1999)

      Su(dx)UAS.cCa/Scer\GAL4Bx-MS1096 rescues Su(dx)sp

      (Cornell et al., 1999)
      Comments

      When expression is driven by Scer\GAL4Bx-MS1096, Su(dx)Scer\UAS.cCa rescues the dominant suppression of dx mutations by Su(dx)sp, and the longitudinal vein gap phenotype of Nnd-1/+, Su(dx)sp/Su(dx)32.

      (Cornell et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Su(dx)Scer\UAS.cCa
      Su(dx)UAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Cornell
      (Cornell et al., 1999)
      Secondary FlyBase IDs
        References (16)