FlyBase Allele Report: Dmel\Hrs[HMS00841]

General Information

Symbol

Dmel\Hrs^HMS00841

Species

D. melanogaster

Name

FlyBase ID

FBal0257521

Feature type

allele

Associated gene

Dmel\Hrs

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00841}

Also Known As

UAS-Hrs-RNAi, HMS00841, hrs RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00841}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00841

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | pupal stage, with Scer\GAL4^ppk.1.9

(Loncle et al., 2015)

increased cell number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

increased size | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

visible, with Scer\GAL4^ap-md544

(O'Farrell et al., 2017)

Phenotype Manifest In

dendrite | pupal stage, with Scer\GAL4^ppk.1.9

(Loncle et al., 2015)

embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

embryonic/larval plasmatocyte | increased number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

extracellular exosome, with Scer\GAL4^dsx.KI

(Corrigan et al., 2014)

larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4^ppk.1.9

(Loncle et al., 2015)

larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.1.9

(Loncle et al., 2015)

male accessory gland secondary cell, with Scer\GAL4^dsx.KI

(Corrigan et al., 2014)

nephrocyte, with Scer\GAL4^Ugt36A1.PK

(Milosavljevic et al., 2022)

nucleus | increased number | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

primary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

secondary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

slit diaphragm, with Scer\GAL4^Ugt36A1.PK

(Milosavljevic et al., 2022)

tertiary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2024)

wing, with Scer\GAL4^ap-md544

(O'Farrell et al., 2017)

Detailed Description

Statement

Reference

The expression of Hrs^HMS00841 under the control of Scer\GAL4^ap-md544 leads to adult wings presenting an upward curvature.

(O'Farrell et al., 2017)

Knockdown of Hrs^HMS00841 driven in the class IV dendritic arborizing sensory neuron ddaC by Scer\GAL4^ppk.1.9 leads to mild disruptions in pruning at 18hr after puparium formation, with minor delay and clearance (but no severing) defects.

Knockdown of Hrs^HMS00841 driven in the class IV dendritic arborizing sensory neuron ddaC by Scer\GAL4^ppk.1.9 leads to accumulation of ubiquitinated proteins (defects in multivesicular body formation) in third instar larvae.

(Loncle et al., 2015)

Expression of Hrs^HMS00841 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} does not result in melanisation of the fat body.

(Zang et al., 2015)

Expression of Hrs^HMS00841 in secondary cells under the control of Scer\GAL4^dsx.KI reduces exosome secretion into the accessory gland lumen compared to controls.

(Corrigan et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^insc-Mz1407/Hrs^HMS00841 is a non-enhancer of increased cell number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Scer\GAL4^insc-Mz1407/Hrs^HMS00841 is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of Vps35^E42