FlyBase Allele Report: Dmel\Atg18a[HMS01193]

General Information

Symbol

Dmel\Atg18a^HMS01193

Species

D. melanogaster

Name

FlyBase ID

FBal0257851

Feature type

allele

Associated gene

Dmel\Atg18a

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01193}

Also Known As

UAS-Atg18a^RNAi, UAS-Atg18-shRNA, UAS-Atg18 RNAi, Atg18a RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01193}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01193

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell cycle | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

abnormal stress response | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

Phenotype Manifest In

adult head sensillum, with Scer\GAL4^neur-P72

(Inagaki et al., 2026)

adult head sensillum, with Scer\GAL4^unspecified

(Inagaki et al., 2026)

cuticular pore | decreased number, with Scer\GAL4^neur-P72

(Inagaki et al., 2026)

endoplasmic reticulum, with Scer\GAL4^unspecified

(Inagaki et al., 2026)

female germline stem cell, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

plasma membrane, with Scer\GAL4^unspecified

(Inagaki et al., 2026)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34714

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01193}attP2

NIG-Fly

HMS01193

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01193}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Atg18^HMS01193

(Clark et al., 2018)

Atg18a^HMS01193

(Inagaki et al., 2026, Billes et al., 2018)

atg18^RNAi

(Zhao et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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