FlyBase Allele Report: Dmel\Dcp-1[RNAi.UAS]

General Information

Symbol

Dmel\Dcp-1^RNAi.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0258027

Feature type

allele

Associated gene

Dmel\Dcp-1

Associated Insertion(s)

Carried in Construct

P{UAS-Dcp-1.RNAi}

Key Links

Transgenic product class

RNAi_reagent

(Lee et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Lee et al., 2011)

Mutagen

in vitro construct

(Lee et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-Dcp-1.RNAi}

Cytology

Description

UAS regulatory sequences drive expression of a transcript encoding two copies of a miRNA that targets the Dcp-1 5' untranslated region.

(Lee et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Dcp-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell death, with Scer\GAL4^Crz.504

(Lee et al., 2011)

Phenotype Manifest In

neuron, with Scer\GAL4^Crz.504

(Lee et al., 2011)

Detailed Description

Statement

Reference

Expression of Dcp-1^{miRNA.Scer\UAS} under the control of Scer\GAL4^Crz.504 blocks vCrz programmed cell death.

(Lee et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Dcp-1^RNAi.UAS, Drice^RNAi.UAS.cMa, Scer\GAL4^Crz.504 has abnormal cell death phenotype

(Lee et al., 2011)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Dcp-1^RNAi.UAS, Scer\GAL4^GMR.PF is a non-suppressor of photoreceptor phenotype of Der-1^UAS.cLa, Scer\GAL4^GMR.PF

(Liang et al., 2014)

Other

Statement

Reference

Dcp-1^RNAi.UAS, Drice^RNAi.UAS.cMa, Scer\GAL4^Crz.504 has neuron phenotype

(Lee et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Dcp-1^{miRNA.Scer\UAS} fails to suppress the photoreceptor degeneration seen when Der-1^Scer\UAS.cLa is expressed under the control of Scer\GAL4^GMR.PF.

(Liang et al., 2014)

Co-expression of Dcp-1^{miRNA.Scer\UAS} and Ice^{miRNA.Scer\UAS} under the control of Scer\GAL4^Crz.504 blocks vCrz programmed cell death with all 16 vCrz neurons retained at 7 and 16 hours after puparium formation, compared to apoptosis of these neurons in wild-type controls.

(Lee et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Generated using the mir6.1 method described in Chen et al., 2007 (FBrf0200061).

(Liang et al., 2014)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dcp-1^RNAi.UAS

Dcp-1^{miRNA.Scer\UAS}

Dcp-1^miRNA.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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