FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sas-4unspecified
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General Information
Symbol
Dmel\Sas-4unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0258390
Feature type
allele
Associated gene
Dmel\Sas-4
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The spindle is correctly oriented in mutant male germline stem cells (GSCs), but the spectrosome is consistently seen at the apical spindle pole, in contrast to wild type, where the spectrosome is located at the distal spindle pole in male GSCs.

        (Yuan et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The brains of mst2 Sas-4unspecified double mutant larvae have a very high mitotic index, with most dividing cells arrested in metaphase with highly contracted chromosomes. More than 95% of metaphases lack centrosomes and these metaphases have very peculiar 'spindles': 34% are devoid of microtubules arrays, 4% have small and disorganised bipolar spindles and 62% have acentrosomal microtubule arrays (AMTAs) resembling monopolar spindles. The AMTAs are always associated with metaphase chromosomes, with some microtubules terminating at the chromosomes, and others extending beyond them.

        (Mottier-Pavie et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Sas-4unspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (5)