FlyBase Allele Report: Dmel\Art1[KK101196]

General Information

Symbol

Dmel\Art1^KK101196

Species

D. melanogaster

Name

FlyBase ID

FBal0258912

Feature type

allele

Associated gene

Dmel\Art1

Associated Insertion(s)

Carried in Construct

P{KK101196}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101196}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101196

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis

modeled by Hsap\FUS^{R521H.UAS.Tag:HA}

(Scaramuzzino et al., 2013)

modeled by Hsap\FUS^UAS.Tag:HA

(Scaramuzzino et al., 2013)

DOES NOT ameliorate amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{UAS.cJa.Tag:HA}

(Jäckel et al., 2015)

exacerbates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{P525L.UAS.cJa.Tag:HA}

(Jäckel et al., 2015)

DOES NOT ameliorate frontotemporal dementia

modeled by Hsap\FUS^{UAS.cJa.Tag:HA}

(Jäckel et al., 2015)

exacerbates frontotemporal dementia

modeled by Hsap\FUS^{P525L.UAS.cJa.Tag:HA}

(Jäckel et al., 2015)

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Ortega et al., 2020)

modeled by Zzzz\GGGGCC^36.UAS

(Ortega et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Art1^KK101196 under the control of Scer\GAL4^GMR.PF does not cause any obvious eye phenotype.

(Scaramuzzino et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Art1^KK101196, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Ortega et al., 2020)

Art1^KK101196, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS

(Ortega et al., 2020)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\FUS^{R495X.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of abnormal eye color phenotype of Hsap\FUS^{R495X.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\FUS^{P525L.UAS.cJa.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Scaramuzzino et al., 2013)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\FUS^{R521H.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Scaramuzzino et al., 2013)

NOT Enhancer of

Statement

Reference

Art1^KK101196, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\FUS^{UAS.cJa.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Art1^KK101196, Scer\GAL4^GMR.PF is a non-enhancer of abnormal eye color phenotype of Hsap\FUS^{UAS.cJa.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Art1^KK101196, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Ortega et al., 2020)

Art1^KK101196, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS

(Ortega et al., 2020)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\FUS^{P525L.UAS.cJa.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of eye | adult stage phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Scaramuzzino et al., 2013)

Art1^KK101196, Scer\GAL4^GMR.PF is an enhancer of eye | adult stage phenotype of Hsap\FUS^{R521H.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Scaramuzzino et al., 2013)

NOT Enhancer of

Statement

Reference

Art1^KK101196, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\FUS^{UAS.cJa.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Art1^KK101196, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\FUS^{R495X.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Jäckel et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Art1^KK101196 enhances the eye defects resulting from the Scer\GAL4^GMR.PF-driven expression of either Hsap\FUS^{P525L.Scer\UAS.cJa.T:Ivir\HA1} or Hsap\FUS^{R495X.Scer\UAS.T:Ivir\HA1}, but does not enhance the eye defects resulting from the Scer\GAL4^GMR.PF-driven expression of Hsap\FUS[Scer\UAS.cJa. T:Ivir \HA1].

(Jäckel et al., 2015)

Co-expression of Art1^KK101196 enhances the eye degeneration phenotype seen in flies expressing Hsap\FUS^{R521H.Scer\UAS.T:Ivir\HA1} or Hsap\FUS^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Scaramuzzino et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110391

P{KK101196}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Art1^KK101196

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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