FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tsrKK108706
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General Information
Symbol
Dmel\tsrKK108706
Species
D. melanogaster
Name
FlyBase ID
FBal0259717
Feature type
allele
Associated gene
Dmel\tsr
Associated Insertion(s)
Carried in Construct
P{KK108706}
Also Known As
UAS-tsr dsRNA, tsr RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK108706}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK108706
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  nemaline myopathy 7
      CEA
      (Balakrishnan et al., 2020)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing tsrKK108706 under the control of Scer\GAL4Mef2.PU leads to larvae showing disruption of muscle fiber structure and sarcomere organization.

      (Balakrishnan et al., 2020)

      Pan-neuronal expression of tsrKK108706 in adult flies (using 31[o]C heat-induced Scer\GAL4nSyb.PS in combination with Scer\GAL80ts.αTub84B) significantly decreases wall following behavior (posited measure of anxiety) in an arena, compared to non-induced (18[o]C) controls.

      (Mohammad et al., 2016)

      The mushroom body axons of flies expressing tsrKK108706 under the control of Scer\GAL4ey-OK107 fail to extend to form peduncles and lobe structures (the 'posterior arrest' phenotype). Scer\GAL4ey-OK107>tsrKK108706 expressing clones that exhibit the posterior arrest phenotype display ectopic regions of F-actin in the posteriorly arrested axons.

      (Abe et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      tsrKK108706 is partially rescued by tsrUAS.Tag:HA/Scer\GAL4Mef2.PU

      (Balakrishnan et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tsrKK108706
      (Mohammad et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (12)