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General Information
Symbol
Dmel\tsrKK108706
Species
D. melanogaster
Name
FlyBase ID
FBal0259717
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
tsr RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing tsrKK108706 under the control of Scer\GAL4Mef2.PU leads to larvae showing disruption of muscle fiber structure and sarcomere organization.

Pan-neuronal expression of tsrKK108706 in adult flies (using 31[o]C heat-induced Scer\GAL4nSyb.PS in combination with Scer\GAL80ts.╬▒Tub84B) significantly decreases wall following behavior (posited measure of anxiety) in an arena, compared to non-induced (18[o]C) controls.

The mushroom body axons of flies expressing tsrKK108706 under the control of Scer\GAL4ey-OK107 fail to extend to form peduncles and lobe structures (the 'posterior arrest' phenotype). Scer\GAL4ey-OK107>tsrKK108706 expressing clones that exhibit the posterior arrest phenotype display ectopic regions of F-actin in the posteriorly arrested axons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (9)