FB2026_02 , released June 18, 2026
Allele: Dmel\Lsd1UAS.mCherry
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General Information
Symbol
Dmel\Lsd1UAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0260642
Feature type
allele
Associated gene
Dmel\Lsd1
Associated Insertion(s)
Carried in Construct
P{UAS-Lsd-1.mCherry}
Key Links
Transgenic product class
wild_type
(Tian et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tian et al., 2011)
Mutagen
in vitro construct
(Tian et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Lsd-1.mCherry}
Cytology
Description

UAS drives expression of the Lsd-1 coding region tagged with mCherry at the C-terminus.

(Tian et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Lsd1
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Lsd-1UAS.mCherry under the control of Scer\GAL4ppl.PU leads to small lipid droplets in the adult fat body; adults are sensitive to infection with S. typhimurium or E. coli (increased mortality and increased bacterial load). Expression under the control of Scer\GAL4Switch1.106, induced by RU486 just before infection, still induces small lipid droplets in the adult fat body and sensitivity to infection.

      (Wang et al., 2021)

      The level of circulating lipid in the hemolymph is increased in larvae expressing Lsd-1Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4tub.PU compared to controls under fed conditions.

      (Bi et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Lsd1UAS.mCherry, Scer\GAL4ppl.PU is a suppressor of abnormal size | larval stage phenotype of Scer\GAL4ppl.PU, mrtF931

      (Yao et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4ppl.PP/Lsd1UAS.mCherry rescues Lsd138

      (Bi et al., 2012)
      Comments

      The reduced survival of Lsd-138 larvae compared to controls under starvation conditions is rescued by expression of Lsd-1Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4ppl.PP.

      Expression of Lsd-1Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4ppl.PP cell-autonomously rescues the large lipid droplet phenotype of Lsd-138 larvae.

      (Bi et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Lsd-1Scer\UAS.T:Disc\RFP-mCherry
      Lsd-1UAS.mCherry
      Lsd1UAS.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (5)