FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sod1RNAi.UAS.cUa
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General Information
Symbol
Dmel\Sod1RNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0407477
Feature type
allele
Associated gene
Dmel\Sod1
Associated Insertion(s)
Carried in Construct
P{UAS-Sod1.RNAi.U}
Key Links
Transgenic product class
RNAi_reagent
(FlyBase Curators, 2025-)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(FlyBase Curators, 2025-)
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-Sod1.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of an RNAi line that targets Sod1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sod1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Sod1dsRNA.UAS.cUa under the control of Scer\GAL4ppl.PU leads to enlarged lipid droplets in the the adult fat body.

      (Wang et al., 2021)

      Glial (Scer\GAL4nrv2.PU) knockdown (SodVDRC.cUa) disrupts 1hr memory in 5 (but not 1) day old flies, and also disrupts anesthesia-resistant memory. Neuronal (Scer\GAL4elav.PU) knockdown (SodVDRC.cUa) disrupts 1hr memory in 10 (but not 1) day old flies.

      (Yamazaki et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4nrv2.PU, Sod1RNAi.UAS.cUa has abnormal memory | adult stage phenotype, non-suppressible by PcbEP2547/PCB[+]

      (Yamazaki et al., 2014)

      Scer\GAL4elav.PU, Sod1RNAi.UAS.cUa has abnormal memory | adult stage phenotype, non-suppressible by PcbEP2547/PCB[+]

      (Yamazaki et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Disruption of 1hr memory via glial (5 day old flies, Scer\GAL4nrv2.PU) or neuronal (10 day old flies, Scer\GAL4elav.PU) knockdown (SodVDRC.cUa) is not ameliorated in a PCBEP2547/+ background.

      (Yamazaki et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Sod1RNAi.UAS.cUa
      Sod1VDRC.cUa
      Sod1dsRNA.UAS.cUa
      SodVDRC.cUa
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0343987
      • FBal0318368
      References (5)