FlyBase Allele Report: Dmel\Mrp4[EP430]

General Information

Symbol

Dmel\Mrp4^EP430

Species

D. melanogaster

Name

FlyBase ID

FBal0261060

Feature type

allele

Associated gene

Dmel\Mrp4

Associated Insertion(s)

P{EP}Mrp4^EP430

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kraut et al., 2001, FlyBase, 1996-)

Progenitor genotype

Associated Insertion(s)

P{EP}Mrp4^EP430

Cytology

Description

P{EP}Mrp4^EP430 is inserted 228 bp upstream of the Mrp4 transcription start site and directs over-expression of Mrp4 in the presence of Scer\GAL4.

(Huang and Haddad, 2007)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:11,569,022..11,569,022 [+]

(Mayer et al., 2009, Buff et al., 2007, Huang and Haddad, 2007, Kraut et al., 2001, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

abnormal stress response, with Scer\GAL4^Act.PU

(Huang and Haddad, 2007)

abnormal stress response, with Scer\GAL4^da.G32

(Huang and Haddad, 2007)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Detailed Description

Statement

Reference

CG14709^EP430 mutant flies show little or no difference to wild-type in whole animal fluor content in small-molecular penetration assays.

(Mayer et al., 2009)

Flies expressing Mrp4^EP3177 using Scer\GAL4^da.G32 or Scer\GAL4^Act.PU display a profound increase in recovery time after anoxia compared with controls.

(Huang and Haddad, 2007)

Mutant larvae expressing CG14709^EP430 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses.

(Kraut et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Mrp4^EP430, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Mrp4^EP430, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: an insertion line that modifies the eye phenotype caused by expression of Ppt1^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF when co-expressed using Scer\GAL4^GMR.PF.

(Buff et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG14709^EP430

Mrp4^EP430

l(3)S097907^EP430

l(3)S097907a^EP430

Name Synonyms

Secondary FlyBase IDs

FBal0157174
FBal0122962
FBal0261008

References (5)

Report Sections

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