FlyBase Allele Report: Dmel\Ncc69[r2]

General Information

Symbol

Dmel\Ncc69^r2

Species

D. melanogaster

Name

FlyBase ID

FBal0261184

Feature type

allele

Associated gene

Dmel\Ncc69

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Leiserson et al., 2011)

Mutagen

P-element activity

(Leiserson et al., 2011)

Progenitor genotype

P{EPgy2}EY00168

(Leiserson et al., 2011)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 8743bp deletion (coordinates 3L:1275902..12384644 , genome release 5).

(Leiserson et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:12,382,802..12,391,544 [-]

Comment:

8743 bp deletion resulting from the imprecise excision of P{EPgy2}EY00168. Extent of deletion from reported coordinates.

(Leiserson et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm | adult stage (with Df(3L)ED4475)

(Schellinger et al., 2022)

abnormal circadian rhythm | adult stage | recessive

(Schellinger et al., 2022)

abnormal locomotor behavior | adult stage

(Schellinger et al., 2022)

abnormal neuroanatomy | third instar larval stage

(Leiserson et al., 2011)

viable

(Leiserson et al., 2011)

Phenotype Manifest In

abdominal nerve | third instar larval stage

(Leiserson et al., 2011)

Detailed Description

Statement

Reference

Ncc69^r2 homozygous and Ncc69^r2/Df(3L)ED4475 transheterozygotes display increased circadian period when under constant darkness; Ncc69^r2 homozygotes also exhibit decreased rhythmicity.

Ncc69^r2 homozygotes exhibit decreased morning anticipation activity.

(Schellinger et al., 2022)

The abdominal nerves of mutant third instar larvae have localised swellings or bulges. The phenotype is completely penetrant, with bulges appearing along the lengths of the nerves in all animals examined. Axons and glia may be separated by a large amount of extracellular space in mutant third larval instar nerves, in contrast to wild type. The mutants survive to adulthood.

Evoked action potential activity in response to trains of tetanic stimuli is unaffected in mutant larvae, even at the highest stimulation frequency tested (100Hz).

(Leiserson et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ncc69^r2 has abnormal locomotor rhythm | adult stage phenotype, suppressible by kcc^KK107965/Scer\GAL4^P2.4.Pdf

(Schellinger et al., 2022)

Ncc69^r2 has abnormal locomotor rhythm | adult stage phenotype, suppressible by kcc^DHS1/kcc[+]

(Schellinger et al., 2022)

Ncc69^r2 has abnormal locomotor rhythm | adult stage phenotype, suppressible by fray^RNAi.UAS/Scer\GAL4^P2.4.Pdf

(Schellinger et al., 2022)

Ncc69^r2 has abnormal locomotor rhythm | adult stage phenotype, suppressible by Wnk^KK102654/Scer\GAL4^P2.4.Pdf

(Schellinger et al., 2022)

Ncc69^r2 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Ncc69^UAS.Tag:HA/Scer\GAL4^Gli-rL82.29

(Leiserson et al., 2011)

NOT Enhancer of

Statement

Reference

Ncc69^r2/Ncc69^r2 is a non-enhancer of decreased size | adult stage phenotype of Scer\GAL4^en.PU, Wnk^HMJ02087

(Yarikipati et al., 2023)

Ncc69^r2 is a non-enhancer of paralytic | larval stage | heat sensitive phenotype of para^ts1

(Leiserson et al., 2011)

NOT Suppressor of

Statement

Reference

Ncc69^r2/Ncc69^r2 is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4^en.PU, Wnk^HMJ02087

(Yarikipati et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ncc69^r2 has abdominal nerve | third instar larval stage phenotype, suppressible | partially by Ncc69^UAS.Tag:HA/Scer\GAL4^Gli-rL82.29

(Leiserson et al., 2011)

NOT Enhancer of

Statement

Reference

Ncc69^r2/Ncc69^r2 is a non-enhancer of wing blade posterior compartment phenotype of Scer\GAL4^en.PU, Wnk^HMJ02087

(Yarikipati et al., 2023)

Suppressor of

Statement

Reference

Ncc69^r2 is a suppressor of adult Malpighian tubule phenotype of Scer\GAL4^c42, Wnk^KK102654

(Wu et al., 2014)

NOT Suppressor of

Statement

Reference

Ncc69^r2/Ncc69^r2 is a non-suppressor of wing blade posterior compartment phenotype of Scer\GAL4^en.PU, Wnk^HMJ02087

(Yarikipati et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Scer\GAL4^c42>Wnk^KK102654 in an Ncc69^r2 mutant genetic background has no effect on K[+] flux.

(Wu et al., 2014)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\SLC12A2^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Gli-rL82.29 partially rescues the bulges seen in the abdominal nerves of Ncc69^r2 larvae.

(Leiserson et al., 2011)

Complementation and Rescue Data

Rescued by

Ncc69^r2 is rescued by Ncc69^UAS.Tag:HA/Scer\GAL4^Gli-rL82.29

(Leiserson et al., 2011)

Partially rescued by

Ncc69^r2 is partially rescued by Ncc69^UAS.Tag:HA/Scer\GAL4^P2.4.Pdf

(Schellinger et al., 2022)

Not rescued by

Ncc69^r2 is not rescued by Ncc69^UAS.Tag:HA/Scer\GAL4^Gli-rL82.29

(Schellinger et al., 2022)

Comments

Expression of Ncc69^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Gli-rL82.29 rescues the bulges seen in the abdominal nerves of Ncc69^r2 larvae.

(Leiserson et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ncc69^r2

(Yarikipati et al., 2023, Schellinger et al., 2022, Stenesen et al., 2019, Wu et al., 2014)

(Leiserson et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

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