FlyBase Allele Report: Dmel\Wnk[KK102654]

Scer\GAL4^en.PU-mediated expression of Wnk^KK102654 results in wing notches and loss of margin bristles. The posterior wing compartment is also reduced in size with high penetrance, which is more pronounced when Scer\GAL4^nub.PU is used to drive expression.

(Serysheva et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Wnk^HMC05157, Wnk^KK102654 has abnormal neuroanatomy | adult stage phenotype, suppressible | partially by Sarm^JF01681, Scer\GAL4^pnr-MD237

(Izadifar et al., 2021)

Suppressor of

Statement

Reference

Wnk^KK102654/Scer\GAL4^P2.4.Pdf is a suppressor of abnormal locomotor rhythm | adult stage phenotype of Ncc69^r2

(Schellinger et al., 2022)

Wnk^KK102654, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Scer\GAL4^en.PU/Wnk^KK102654 is a suppressor of lethal phenotype of Scer\GAL4^en.PU, fz2^{2-2-2.UAS.Tag:MYC}

(Serysheva et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^sev.PU/Wnk^KK102654 is a non-suppressor of abnormal planar polarity phenotype of dsh^sev.PU

(Serysheva et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, Wnk^HMC05157, Wnk^KK102654 has axon | adult stage phenotype, suppressible | partially by Sarm^JF01681, Scer\GAL4^pnr-MD237

(Izadifar et al., 2021)

Scer\GAL4^pnr-MD237, Wnk^HMC05157, Wnk^KK102654 has adult mechanosensory neuron phenotype, suppressible | partially by Sarm^JF01681, Scer\GAL4^pnr-MD237

(Izadifar et al., 2021)

Scer\GAL4^c42, Wnk^KK102654 has adult Malpighian tubule phenotype, suppressible by Scer\GAL4^c42/fray^T206E.UAS

(Wu et al., 2014)

Scer\GAL4^c42, Wnk^KK102654 has adult Malpighian tubule phenotype, suppressible by Ncc69^r2

(Wu et al., 2014)

Scer\GAL4^c42, Wnk^KK102654 has adult Malpighian tubule phenotype, suppressible by Scer\GAL4^c42/fray^RNAi.UAS

(Wu et al., 2014)

Suppressor of

Statement

Reference

Wnk^KK102654, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Wnk^KK102654, Scer\GAL4^GMR.PF is a suppressor of photoreceptor phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Scer\GAL4^sev.PU/Wnk^KK102654 is a suppressor of eye photoreceptor cell phenotype of dsh^sev.PU

(Serysheva et al., 2013)

Scer\GAL4^dpp.blk1/Wnk^KK102654 is a suppressor of wing margin bristle | ectopic phenotype of Scer\GAL4^dpp.blk1, fz2^{2-2-2.UAS.Tag:MYC}

(Serysheva et al., 2013)

Other

Statement

Reference

Scer\GAL4^dpp.blk1, Wnk^KK102654, fz2^{2-2-2.UAS.Tag:MYC} has wing margin phenotype

(Serysheva et al., 2013)

Scer\GAL4^en.PU, Wnk^KK102654, fz2^{2-2-2.UAS.Tag:MYC} has wing margin phenotype

(Serysheva et al., 2013)

Scer\GAL4^en.PU, Wnk^KK102654, fz2^{2-2-2.UAS.Tag:MYC} has wing margin bristle phenotype

(Serysheva et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of fray^{T206E.Scer\UAS} is sufficient to rescue the decreased K[+] flux seen in Scer\GAL4^c42>Wnk^KK102654 tubules back to control levels.

Expression of Scer\GAL4^c42>Wnk^KK102654 in an Ncc69^r2 mutant genetic background has no effect on K[+] flux.

Expression of Scer\GAL4^c42>fray^{dsRNA.Scer\UAS} in an Ncc69^r2 mutant genetic background has no effect on K[+] flux.

(Wu et al., 2014)

Scer\GAL4^sev.PU-mediated expression of Wnk^KK102654 specifically suppresses the loss of photoreceptor phenotype without any consistent effect on the planar cell polarity phenotype of dsh^sev.PU eyes.

Co-expression of Wnk^KK102654 suppresses the ectopic margin bristles seen in Scer\GAL4^dpp.blk1 fz2^{2-2-2.Scer\UAS.T:Hsap\MYC} wings - such wings also show a loss of wing margin.

Co-expression of Wnk^KK102654 suppresses the lethality of Scer\GAL4^en.PU fz2^{2-2-2.Scer\UAS.T:Hsap\MYC}. Wings of surviving animals show partial loss of wing margin and lack margin bristles.

(Serysheva et al., 2013)

Xenogenetic Interactions

Statement

Reference

Expression of Wnk^KK102654 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

(Park et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106928

P{KK102654}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG7177^KK102654

Wnk^KK102654

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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