FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\frayT206E.UAS
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General Information
Symbol
Dmel\frayT206E.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0300918
Feature type
allele
Associated gene
Dmel\fray
Associated Insertion(s)
Carried in Construct
M{UAS-fray.T206E}
Also Known As
UAS-frayT206E
Key Links
Transgenic product class
missense_variant
(Wu et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wu et al., 2014)
Mutagen
in vitro construct
(Wu et al., 2014)
Progenitor genotype
Carried in construct
M{UAS-fray.T206E}
Cytology
Description

UAS regulatory sequences drive expression of a constitutively active mutant fray polypeptide carrying amino acid substitution T206E.

(Wu et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fray
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing frayT206E.UAS under the control of Scer\GAL4P2.4.Pdf show increased circadian period when under constant darkness.

      (Schellinger et al., 2022)

      Expression of Scer\GAL4c42>frayT206E.Scer\UAS fails to increase K[+] flux in Malpighian tubules.

      (Wu et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4c42/frayT206E.UAS is a suppressor of adult Malpighian tubule phenotype of Scer\GAL4c42, WnkKK102654

      (Wu et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of frayT206E.Scer\UAS is sufficient to rescue the decreased K[+] flux seen in Scer\GAL4c42>WnkKK102654 tubules back to control levels.

      (Wu et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      frayT206E.Scer\UAS
      frayT206E.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)