FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\groDD.UASp
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General Information
Symbol
Dmel\groDD.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0261192
Feature type
allele
Associated gene
Dmel\gro
Associated Insertion(s)
Carried in Construct
P{UASp-gro.DD}
Key Links
Transgenic product class
missense_variant
(Cinnamon et al., 2008)
polypeptide_post_translational_processing_variant
(Cinnamon et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Cinnamon et al., 2008)
polypeptide_post_translational_processing_variant
(Cinnamon et al., 2008)
Mutagen
in vitro construct
(Cinnamon et al., 2008)
Progenitor genotype
Carried in construct
P{UASp-gro.DD}
Cytology
Description

UASp regulatory sequences drive expression of a mutated form of gro, in which the phospho-acceptor residues within the two rl consensus sites of gro are replaced with phosphomimetic aspartates.

(Cinnamon et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
gro
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of groDD.Scer\UAS.P\T under the control of Scer\GAL4109-30, in combination with gal80[ts] to restrict expression to adulthood, leads to a significant increase in the frequency of multilayered or elongated basal stalks, as compared to controls.

      (Johnston et al., 2016)

      Maternal expression of groDD.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in 51% loss of the intermediate neuroblast column of the neuroectoderm in embryos.

      (Helman et al., 2011)

      Maternal expression of groDD.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in early lethality. Most of the dead larvae show a fully extended filzkorper, with only 11.% showing defects in the terminal structures.

      (Cinnamon et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      GroDD
      (Cinnamon et al., 2008)
      groDD.Scer\UAS.P\T
      groDD.UASp
      groDD
      (Johnston et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)